Chan Brandon A, Xuan Sunting, Li Ang, Simpson Jessica M, Sternhagen Garrett L, Yu Tianyi, Darvish Omead A, Jiang Naisheng, Zhang Donghui
Department of Chemistry and Macromolecular Studies Group, Louisiana State University, Baton Rouge, 70803, Los Angeles.
Biopolymers. 2018 Jan;109(1). doi: 10.1002/bip.23070. Epub 2017 Oct 25.
Polypeptoids, a class of peptidomimetic polymers, have emerged at the forefront of macromolecular and supramolecular science and engineering as the technological relevance of these polymers continues to be demonstrated. The chemical and structural diversity of polypeptoids have enabled access to and adjustment of a variety of physicochemical and biological properties (eg, solubility, charge characteristics, chain conformation, HLB, thermal processability, degradability, cytotoxicity and immunogenicity). These attributes have made this synthetic polymer platform a potential candidate for various biomedical and biotechnological applications. This review will provide an overview of recent development in synthetic methods to access polypeptoid polymers with well-defined structures and highlight some of the fundamental physicochemical and biological properties of polypeptoids that are pertinent to the future development of functional materials based on polypeptoids.
聚肽，一类拟肽聚合物，随着这些聚合物的技术相关性不断得到证明，已成为大分子和超分子科学与工程领域的前沿。聚肽的化学和结构多样性使得能够获得并调节各种物理化学和生物学性质（如溶解性、电荷特性、链构象、亲水亲油平衡、热加工性、可降解性、细胞毒性和免疫原性）。这些特性使这个合成聚合物平台成为各种生物医学和生物技术应用的潜在候选者。本综述将概述合成具有明确结构的聚肽聚合物的方法的最新进展，并突出一些与基于聚肽的功能材料未来发展相关的聚肽的基本物理化学和生物学性质。
