Adhikary Arun K
Infectious Disease Surveillance Centre, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Unit of Microbiology, Faculty of Medicine, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia.
J Med Microbiol. 2017 Nov;66(11):1616-1622. doi: 10.1099/jmm.0.000625. Epub 2017 Oct 25.
Recently, human adenovirus type 3 (HAdV-3) has become the most isolated HAdV worldwide. Restriction endonuclease analysis of globally isolated strains of HAdV-3 has uncovered 51 genome types to date. Information on the genome type is important to the epidemiological study of HAdV-3. In this study, analysis of 75 isolates of HAdV- 3 collected over a 24-year period in Fukui revealed: (1) the emergence of three novel genome types (HAdV-3a52, HAdV-3a53 and HAdV-3a54) and two known genome types (HAdV-3a and HAdV-3a54); (2) the spectrum of diseases caused by individual genome types and their major involvement in the paediatric age population; and (3) the co-circulation and replacement of genome types as a usual phenomenon. The rising number of HAdV-3 genome types indicates that the genetic variation of HAdV-3 is more than other HAdVs. Considering the clinical importance of HAdV-3 infection, its genetic diversity underscores the need for its continuous surveillance and genetic characterization.
最近，3型人腺病毒（HAdV-3）已成为全球分离出的最常见的腺病毒。对全球分离出的HAdV-3菌株进行的限制性内切酶分析迄今已发现51种基因组类型。基因组类型信息对于HAdV-3的流行病学研究很重要。在本研究中，对福井县在24年期间收集的75株HAdV-3进行分析后发现：（1）出现了三种新的基因组类型（HAdV-3a52、HAdV-3a53和HAdV-3a54）以及两种已知的基因组类型（HAdV-3a和HAdV-3a54）；（2）各基因组类型所引发疾病的范围及其主要累及儿童年龄组人群；（3）基因组类型的共同流行和更替是一种常见现象。HAdV-3基因组类型数量的增加表明，HAdV-3的基因变异比其他腺病毒更多。鉴于HAdV-3感染的临床重要性，其遗传多样性凸显了对其持续监测和基因特征分析的必要性。
