Bartell Scott M
Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine , Irvine, California, USA.
Department of Statistics, Donald Bren School of Information and Computer Sciences, University of California, Irvine , Irvine, California, USA.
Environ Health Perspect. 2017 Oct 24;125(10):104502. doi: 10.1289/EHP2820.
Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that has been detected in >100 public water systems in the United States alone. A variety of epidemiological investigations of PFOA have been published, mostly using measured or modeled serum PFOA concentrations as the exposure metric. Comparison of drinking water PFOA concentrations to those study findings or to typical serum concentrations requires pharmacokinetic modeling. This brief communication describes an online Javascript calculator that easily plots the expected serum PFOA concentration over time and at steady state for adults after starting or stopping consumption of PFOA-contaminated water. Two examples of usage are provided, including increasing serum PFOA after ongoing consumption of contaminated water at the federal limit, and decreasing serum PFOA after carbon filtration began in a contaminated water system. https://doi.org/10.1289/EHP2820.
全氟辛酸（PFOA）是一种持久性环境污染物，仅在美国就已在100多个公共供水系统中被检测到。已经发表了多种关于PFOA的流行病学调查，大多使用测量或模拟的血清PFOA浓度作为暴露指标。将饮用水中PFOA浓度与这些研究结果或典型血清浓度进行比较需要药代动力学建模。本简短通讯介绍了一个在线Javascript计算器，该计算器可轻松绘制出成年人开始或停止饮用受PFOA污染的水后，随时间变化以及在稳态下预期的血清PFOA浓度。文中提供了两个使用示例，包括持续饮用受污染水且达到联邦限量后血清PFOA升高的情况，以及在受污染水系统中开始进行碳过滤后血清PFOA降低的情况。https://doi.org/10.1289/EHP2820
