Max-Planck-Institute of Neurobiology, Martinsried, Germany.
Acta Neurol Scand. 2017 Nov;136 Suppl 201:22-25. doi: 10.1111/ane.12843.
This paper argues that multiple sclerosis (MS) is the result of an autoimmune attack against components of the central nervous system (CNS). The effector cells involved in the pathogenic process are CNS-autoreactive T cells present in the healthy immune system in a resting state. Upon activation, these cells cross the blood-brain barrier and attack the CNS target tissue. Recent evidence indicates that autoimmune activation may happen in the intestine, following an interaction of bacterial components of the gut flora with local CNS autoreactive T cells. The consequences of this concept are discussed.
本文认为，多发性硬化症 (MS) 是针对中枢神经系统 (CNS) 成分的自身免疫攻击的结果。参与致病过程的效应细胞是存在于健康免疫系统中的静息状态下的中枢神经系统自身反应性 T 细胞。这些细胞在被激活后会穿过血脑屏障并攻击中枢神经系统靶组织。最近的证据表明，自身免疫激活可能发生在肠道中，肠道菌群的细菌成分与局部中枢神经系统自身反应性 T 细胞相互作用后会引发这种情况。本文讨论了这一概念的后果。
