Janikowska Grażyna, Żebrowska Aleksandra, Kochańska-Dziurowicz Aleksandra, Mazurek Urszula
Department of Analytical Chemistry, Medical University of Silesia, Katowice, Poland.
Department of Physiology, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.
Adv Clin Exp Med. 2017 Sep;26(6):999-1004. doi: 10.17219/acem/63031.
Regular and moderate exercise is beneficial for improving the efficiency of the heart, but high-intensity physical activity may result in cardiac changes.
This study focuses on the identification of the differences in echocardiography and blood variables before exercise, as well as the genes associated with cardiac hypertrophy at rest and in response to graded exercise test.
The study group was made up of 28 road cyclists. Echocardiographic parameters and blood pressure were measured before exercise tests (N = 28). Blood samples were collected at rest, at maximal exercise intensity in a graded bicycle test and after 15 min of recovery; afterwards, blood morphology was estimated and RNA was isolated. Analysis of the expression profile of genes was performed for randomly selected road cyclists using the microarray method.
Echocardiographic results and blood parameters divided cyclists into two groups: with and without left ventricular hypertrophy (N = 14). Differences in the structure and function of the left ventricle cyclists with a similar level of training were observed (p < 0.05). Diastolic blood pressure and resting heart rate were significantly lower in subjects with left ventricular hypertrophy (p < 0.05). The myosin light chain 9 and interleukin-6 signal transducer gene expression were differentially regulated in cyclists with left ventricular hypertrophy compared to athletes with normal heart dimensions in response to intensive exercise.
We have found differences in echocardiography parameters, blood pressure, stroke volume and maximal power in the cyclists examined. These studies indicate the benefits of the recommended echocardiography measurements for professional endurance-athletes. The graded exercise altered the myosin light chain 9 and interleukin-6 signal transducer gene expression in the peripheral blood of road cyclists has also been found.
规律且适度的运动有益于提高心脏效率，但高强度体育活动可能导致心脏变化。
本研究着重于识别运动前超声心动图和血液变量的差异，以及与静息时和分级运动试验反应性心脏肥大相关的基因。
研究组由28名公路自行车运动员组成。在运动试验前（N = 28）测量超声心动图参数和血压。在静息时、分级自行车试验的最大运动强度时以及恢复15分钟后采集血样；随后，评估血液形态并分离RNA。使用微阵列方法对随机选择的公路自行车运动员进行基因表达谱分析。
超声心动图结果和血液参数将自行车运动员分为两组：有和无左心室肥大（N = 14）。观察到训练水平相似的自行车运动员左心室结构和功能存在差异（p < 0.05）。左心室肥大受试者的舒张压和静息心率显著更低（p < 0.05）。与心脏尺寸正常的运动员相比，左心室肥大的自行车运动员在剧烈运动时肌球蛋白轻链9和白细胞介素-6信号转导子基因表达受到不同调节。
我们在接受检查的自行车运动员中发现了超声心动图参数、血压、每搏输出量和最大功率方面的差异。这些研究表明推荐的超声心动图测量对职业耐力运动员的益处。还发现分级运动改变了公路自行车运动员外周血中肌球蛋白轻链9和白细胞介素-6信号转导子基因的表达。
