Owczarek Katarzyna, Lewandowska Urszula
a Department of Biochemistry , Faculty of Medicine, Medical University of Lodz , Lodz , Poland.
Nutr Cancer. 2017 Nov-Dec;69(8):1105-1118. doi: 10.1080/01635581.2017.1367940. Epub 2017 Oct 25.
Polyphenols are natural compounds with high structural diversity whose common occurrence in plants renders them intrinsic dietary components. They are known to be secondary metabolites characterized by a wide spectrum of biological activities, and a growing body of evidence indicates they have anti-inflammatory potential. It is well known that inflammation plays a key role in many chronic diseases such as circulatory diseases, pulmonary diseases, autoimmune diseases, diabetes, cancer, and neurodegenerative diseases. Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, and TNF-α, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid. Furthermore, polyphenols exhibit anti-inflammatory activity on many levels via NF-κB inhibition, and MAPK, iNOS, and growth factors regulation. This paper reviews the current state of knowledge concerning the potential of various dietary polyphenols to inhibit the effects of COX-2 in colon cancer, by examining the available evidence regarding the efficacy and safety of these compounds obtained from in vitro and animal studies.
多酚是一类结构高度多样的天然化合物，因其在植物中广泛存在，故而是饮食中的固有成分。众所周知，它们是具有广泛生物活性的次生代谢产物，越来越多的证据表明它们具有抗炎潜力。众所周知，炎症在许多慢性疾病如循环系统疾病、肺部疾病、自身免疫性疾病、糖尿病、癌症和神经退行性疾病中起关键作用。多酚通过控制和抑制促炎细胞因子如白细胞介素-1β、白细胞介素-6、白细胞介素-8和肿瘤坏死因子-α以及参与花生四烯酸代谢的环氧化酶-2（COX-2）酶来影响炎症过程。此外，多酚通过抑制核因子-κB以及调节丝裂原活化蛋白激酶、诱导型一氧化氮合酶和生长因子，在多个层面展现出抗炎活性。本文通过审视从体外和动物研究中获得的有关这些化合物疗效和安全性的现有证据，综述了关于各种膳食多酚抑制COX-2在结肠癌中作用的潜在性的当前知识状况。
