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Novel antipsychotic drugs share high affinity for sigma receptors.

作者信息

Largent B L, Wikström H, Snowman A M, Snyder S H

机构信息

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

出版信息

Eur J Pharmacol. 1988 Oct 18;155(3):345-7. doi: 10.1016/0014-2999(88)90527-4.

DOI:10.1016/0014-2999(88)90527-4
PMID:2906878
Abstract
摘要

相似文献

1
Novel antipsychotic drugs share high affinity for sigma receptors.新型抗精神病药物对σ受体具有高亲和力。
Eur J Pharmacol. 1988 Oct 18;155(3):345-7. doi: 10.1016/0014-2999(88)90527-4.
2
The sigma receptor: a novel site implicated in psychosis and antipsychotic drug efficacy.西格玛受体：一个与精神病及抗精神病药物疗效相关的新位点。
Clin Neuropharmacol. 1988 Apr;11(2):105-19.
3
1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8784-8. doi: 10.1073/pnas.83.22.8784.
4
Neuroleptic drugs and the sigma receptor.
Am J Psychiatry. 1990 Aug;147(8):1093-4. doi: 10.1176/ajp.147.8.1093.
5
Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.西格玛阿片类药物和某些抗精神病药物在豚鼠脑膜中相互抑制（+）-[3H]SKF 10,047和[3H]氟哌啶醇的结合。
Proc Natl Acad Sci U S A. 1984 Sep;81(17):5618-21. doi: 10.1073/pnas.81.17.5618.
6
Subchronic treatment of rats with remoxipride fails to modify sigma binding sites in the brain.用瑞莫必利对大鼠进行亚慢性治疗未能改变大脑中的σ结合位点。
Eur J Pharmacol. 1992 Jun 5;226(2):157-61. doi: 10.1016/0922-4106(92)90177-w.
7
Haloperidol competitively inhibits the binding of (+)-[3H]SKF-10,047 to sigma sites.
Eur J Pharmacol. 1990 May 16;180(2-3):361-4. doi: 10.1016/0014-2999(90)90322-w.
8
Polyamines non-competitively inhibit [3H]3-PPP binding to sigma receptors.多胺非竞争性抑制[3H]3 - PPP与σ受体的结合。
Eur J Pharmacol. 1990 Aug 2;184(1):203-4. doi: 10.1016/0014-2999(90)90685-y.
9
The sigma enigma: biochemical and functional correlates emerge for the haloperidol-sensitive sigma binding site.西格玛之谜：针对氟哌啶醇敏感的西格玛结合位点，出现了生化与功能相关性。
Trends Pharmacol Sci. 1990 Jun;11(6):213-5. doi: 10.1016/0165-6147(90)90241-y.
10
Quantitative conformational analyses predict distinct receptor sites for PCP-like and sigma drugs.
Eur J Pharmacol. 1987 Dec 1;144(2):231-5. doi: 10.1016/0014-2999(87)90524-3.

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When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists.在寒冷环境中给大鼠施用3,4-亚甲基二氧甲基苯丙胺时，它会降低棕色脂肪组织的产热并增加尾部血流量：5-HT1A和多巴胺D2拮抗剂预处理的影响。
Neuroscience. 2008 Jul 17;154(4):1619-26. doi: 10.1016/j.neuroscience.2008.04.041. Epub 2008 May 2.
2
Cannabis-associated psychosis: current status of research.大麻所致精神病：研究现状
CNS Drugs. 2004;18(13):895-910. doi: 10.2165/00023210-200418130-00005.
3
Pharmacology of the atypical antipsychotic remoxipride, a dopamine D2 receptor antagonist.
非典型抗精神病药物瑞莫必利（一种多巴胺D2受体拮抗剂）的药理学
CNS Drug Rev. 2001 Fall;7(3):265-82. doi: 10.1111/j.1527-3458.2001.tb00199.x.
4
Characterization of [3H]pentazocine binding sites in post-mortem human frontal cortex.
J Neural Transm (Vienna). 1996;103(1-2):45-53. doi: 10.1007/BF01292615.
5
BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats.
J Neural Transm (Vienna). 1996;103(10):1153-61. doi: 10.1007/BF01271200.
6
Blockade by sigma site ligands of N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurones.N-甲基-D-天冬氨酸诱发的大鼠和小鼠培养海马锥体神经元反应被σ位点配体阻断。
Br J Pharmacol. 1995 Dec;116(7):2791-800. doi: 10.1111/j.1476-5381.1995.tb15928.x.
7
Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine: a new model of schizophrenia.苯环己哌啶亚急性或重复给药增强强迫游泳试验中的不动时间：一种新的精神分裂症模型
Br J Pharmacol. 1995 Nov;116(5):2531-7. doi: 10.1111/j.1476-5381.1995.tb15106.x.
8
The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents.甘氨酸/N-甲基-D-天冬氨酸受体拮抗剂R-(+)-HA-966可阻断苯环利定和地佐环平（MK-801）在啮齿动物中诱导的中脑边缘多巴胺能系统的激活。
Br J Pharmacol. 1993 Apr;108(4):1156-63. doi: 10.1111/j.1476-5381.1993.tb13520.x.
9
Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors.抗精神病药物在体外和体内与神经递质受体位点的相互作用及其与药理和临床效应的关系：5HT2受体的作用
Psychopharmacology (Berl). 1993;112(1 Suppl):S40-54. doi: 10.1007/BF02245006.
10
An examination of the putative sigma-receptor in the mouse isolated vas deferens.对小鼠离体输精管中假定的σ受体的研究。
Br J Pharmacol. 1989 Oct;98(2):429-36. doi: 10.1111/j.1476-5381.1989.tb12614.x.