Ridway J C, Taylor G M, Harris R
J Immunol Methods. 1979;29(3):271-7. doi: 10.1016/0022-1759(79)90315-6.
A comparison has been made between assays of Fc receptor bearing cells among blood leucocytes from normal individuals and from patients with myeloid leukaemia, using human anti-D coated erythrocytes (HEA) and sheep erythrocytes sensitised with a rabbit anti-sheep erythrocyte antibody (SEA). Differences were found between the assays in both groups, demonstrating the heterogeneity of Fc receptors with respect to affinity for marker, and for Fc bearing leucocytes. Monocytoid cells reacted more readily with both markers than myeloid cells. The HEA rosette assay may be useful selective diagnostic aid for Fc+ myeloid leukaemia since the SEA assay detects Fc receptors on mature granulocytes.
利用人抗 D 包被红细胞（HEA）和用兔抗绵羊红细胞抗体致敏的绵羊红细胞（SEA），对正常个体和髓系白血病患者血液白细胞中携带 Fc 受体的细胞进行了检测比较。两组检测结果存在差异，表明 Fc 受体在对标记物的亲和力以及对携带 Fc 的白细胞方面具有异质性。单核样细胞比髓系细胞更容易与两种标记物发生反应。由于 SEA 检测可检测成熟粒细胞上的 Fc 受体，因此 HEA 玫瑰花结检测可能是诊断 Fc⁺髓系白血病的一种有用的选择性诊断辅助方法。
