Comte Magali, Zendjidjian Xavier Y, Coull Jennifer T, Cancel Aïda, Boutet Claire, Schneider Fabien C, Sage Thierry, Lazerges Pierre-Emmanuel, Jaafari Nematollah, Ibrahim El Chérif, Azorin Jean-Michel, Blin Olivier, Fakra Eric
Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France.
Department of Psychiatry, La Conception University Hospital, Marseille, France.
Soc Cogn Affect Neurosci. 2018 Apr;13(4):381-390. doi: 10.1093/scan/nsx083. Epub 2017 Oct 23.
Functional dysconnection is increasingly recognized as a core pathological feature in schizophrenia. Aberrant interactions between regions of the cortico-limbic circuit may underpin the abnormal emotional processing associated with this illness. We used a functional magnetic resonance imaging (fMRI) paradigm designed to dissociate the various components of the cortico-limbic circuit (i.e. a ventral automatic circuit that is intertwined with a dorsal cognitive circuit), in order to explore bottom-up appraisal as well as top-down control during emotion processing. In schizophrenia patients compared to healthy controls, bottom-up processes were associated with reduced interaction between the amygdala and both the anterior cingulate cortex (ACC) and the dorsolateral prefrontal cortex (DLPFC). Contrariwise, top-down control processes led to stronger connectivity between the ventral affective and the dorsal cognitive circuits, i.e. heightened interactions between the ventral ACC and the DLPFC as well as between dorsal and ventral ACC. These findings offer a comprehensive view of the cortico-limbic dysfunction in schizophrenia. They confirm previous results of impaired propagation of information between the amygdala and the prefrontal cortex and suggest a defective functional segregation in the dorsal cognitive part of the cortico-limbic circuit.
功能失调连接日益被认为是精神分裂症的核心病理特征。皮质-边缘回路各区域之间的异常相互作用可能是该疾病相关异常情绪加工的基础。我们使用了一种功能磁共振成像（fMRI）范式，旨在区分皮质-边缘回路的各个组成部分（即与背侧认知回路交织在一起的腹侧自动回路），以探索情绪加工过程中的自下而上评估以及自上而下控制。与健康对照相比，精神分裂症患者的自下而上过程与杏仁核与前扣带回皮质（ACC）和背外侧前额叶皮质（DLPFC）之间的相互作用减少有关。相反，自上而下控制过程导致腹侧情感回路和背侧认知回路之间更强的连接，即腹侧ACC与DLPFC之间以及背侧和腹侧ACC之间的相互作用增强。这些发现提供了精神分裂症皮质-边缘功能障碍的全面观点。它们证实了先前关于杏仁核与前额叶皮质之间信息传递受损的结果，并表明皮质-边缘回路背侧认知部分存在功能性分离缺陷。
