a Department of Pharmacy and Health and Nutrition Sciences , University of Calabria , Rende (CS) , Italy.
Drug Deliv. 2017 Dec;24(sup1):33-44. doi: 10.1080/10717544.2017.1386733.
Nowadays, an exciting challenge in the drug chemistry and technology research is represented by the development of methods aimed to protect molecular integrity and therapeutic activity of drugs from effects of light. The photostability characterization is ruled by ICH (The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use), which releases details throughout basic protocols of stability tests to be performed on new medicinal products for human use. The definition of suitable photoprotective systems is fundamental for pharmaceutical manufacturing and for human healthy as well, since light exposure may affect either drugs or drug formulations giving rise even to allergenic or mutagenic by-products. Here, we summarize and discuss the recent studies on the formulation of photosensitive drugs into supramolecular systems, capable of entrapping the molecules in a hollow of their structure by weak noncovalent interactions and protecting them from light. The best known supramolecular matrices belong to the 'auto-assembled' structures, of which liposomes are the most representative, and the 'host-guest' systems, of which cyclodextrins represent the most common 'host' counterpart. A relevant number of papers concerning the use of both liposomes and cyclodextrins as photoprotection systems for drugs has been published over the last 20 years, demonstrating that this topic captures interest in an increasing number of researchers.
如今，药物化学和技术研究中的一个令人兴奋的挑战是开发旨在保护药物的分子完整性和治疗活性免受光影响的方法。光稳定性表征受 ICH（人用药物国际协调理事会）的监管，ICH 发布了在人类新药物的稳定性测试中要执行的基本方案的详细信息。合适的光保护系统的定义对于药物制造以及人类健康都是至关重要的，因为光暴露可能会影响药物或药物制剂，甚至产生过敏原或诱变副产品。在这里，我们总结并讨论了将光敏感药物制剂成超分子系统的最新研究，这些系统能够通过弱非共价相互作用将分子困在其结构的中空部分，并保护它们免受光的影响。最著名的超分子基质属于“自组装”结构，其中脂质体是最具代表性的，而“主体-客体”系统，其中环糊精是最常见的“主体”对应物。在过去的 20 年中，已经发表了大量关于使用脂质体和环糊精作为药物光保护系统的论文，这表明这个主题吸引了越来越多的研究人员的兴趣。
