异山梨醇二硝酸酯对静脉给药系统的吸附作用。

The sorption of isosorbide dinitrate to intravenous delivery systems.

作者信息

De Muynck C, Remon J P, Colardyn F

机构信息

Laboratory of Pharmaceutical Technology, State University of Gent, Belgium.

出版信息

J Pharm Pharmacol. 1988 Sep;40(9):601-4. doi: 10.1111/j.2042-7158.1988.tb05317.x.

DOI:10.1111/j.2042-7158.1988.tb05317.x

PMID:2907024

Abstract

The sorption of isosorbide dinitrate from 0.9% sodium chloride and 10% glucose solutions, by intravenous delivery systems has been investigated under simulated infusion conditions. Isosorbide dinitrate was stable in both 0.9% sodium chloride and 10% glucose solutions. Intravenous fluid containers, burettes, a syringe, infusion sets and end-line filters were evaluated. Glass containers, methacrylate butadiene styrene burettes and polybutadiene giving sets did not sorb isosorbide dinitrate. Neither did polypropylene syringes when a 10% glucose solution was used. The sorption of isosorbide dinitrate to end-line filters was unimportant but there was a significant loss to the PVC tubing used to connect the filter housing to the catheter.

摘要

在模拟输注条件下，对静脉给药系统从0.9%氯化钠溶液和10%葡萄糖溶液中吸附硝酸异山梨酯的情况进行了研究。硝酸异山梨酯在0.9%氯化钠溶液和10%葡萄糖溶液中均稳定。对静脉输液容器、滴管、注射器、输液器和终端过滤器进行了评估。玻璃容器、甲基丙烯酸丁二烯苯乙烯滴管和聚丁二烯输液器不吸附硝酸异山梨酯。当使用10%葡萄糖溶液时，聚丙烯注射器也不吸附。硝酸异山梨酯对终端过滤器的吸附并不重要，但用于连接过滤器外壳和导管的聚氯乙烯（PVC） tubing有明显的损失。