Cossum P A, Roberts M S
Eur J Clin Pharmacol. 1981 Feb;19(3):181-5. doi: 10.1007/BF00561946.
The loss of isosorbide dinitrate from aqueous solutions stored in plastic infusion bags and/or infused through plastic giving sets was investigated. During simulated infusions, the loss of isosorbide dinitrate was found to be flow-rate dependent. The clinical and pharmacokinetic significance of this loss is discussed. Infusion o isosorbide dinitrate from a glass syringe through high density polyethylene tubing overcame the loss associated with its administration via plastic infusion bags and intravenous giving sets. This method was also applied successfully to minimise the previously reported loss of diazepam and chlormethiazole during infusions.
研究了硝酸异山梨酯在储存在塑料输液袋和/或通过塑料输液器输注的水溶液中的损失情况。在模拟输注过程中，发现硝酸异山梨酯的损失与流速有关。讨论了这种损失的临床和药代动力学意义。通过高密度聚乙烯管从玻璃注射器输注硝酸异山梨酯克服了通过塑料输液袋和静脉输液器给药时的损失。该方法也成功应用于尽量减少先前报道的输注过程中地西泮和氯美噻唑的损失。
