5-单硝酸异山梨酯在静脉给药系统中的吸附作用。
The sorption of isosorbide-5-mononitrate to intravenous delivery systems.
作者信息
De Muynck C, Colardyn F, Remon J P
机构信息
Laboratory of Pharmaceutical Technology, State University of Gent, Belgium.
出版信息
J Pharm Pharmacol. 1990 Jun;42(6):433-4. doi: 10.1111/j.2042-7158.1990.tb06585.x.
Abstract
The sorption of isosorbide-5-mononitrate, diluted in 0.9% NaCl or 10% glucose solutions, to intravenous delivery systems was investigated. Infusion bags, burettes, a syringe, infusion tubings and end-line filters were tested in static and in dynamic experiments. No clinically significant sorption was detected during those experiments. The use of PVC tubings of different hardness did not influence the results.
摘要
研究了稀释于0.9%氯化钠或10%葡萄糖溶液中的5-单硝酸异山梨酯在静脉给药系统中的吸附情况。在静态和动态实验中对输液袋、滴定管、注射器、输液管和终端过滤器进行了测试。在这些实验中未检测到具有临床意义的吸附。使用不同硬度的聚氯乙烯管并未影响实验结果。
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