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Further Evidence Supporting a Protective Role of Transforming Growth Factor-β (TGFβ) in Aortic Aneurysm and Dissection.

作者信息

Tellides George

机构信息

From the Department of Surgery and Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT; and Veterans Affairs Connecticut Healthcare System, West Haven.

出版信息

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):1983-1986. doi: 10.1161/ATVBAHA.117.310031.

DOI:10.1161/ATVBAHA.117.310031
PMID:29070536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5824991/
Abstract
摘要

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本文引用的文献

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TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms.转化生长因子-β（TGF-β）信号通过不同机制保护胸主动脉和腹主动脉免受血管紧张素II诱导的病变。
Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2102-2113. doi: 10.1161/ATVBAHA.117.309401. Epub 2017 Jul 20.
2
Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling.马凡综合征小鼠模型中的主动脉病变并非由转化生长因子β信号改变介导。
J Am Heart Assoc. 2017 Jan 24;6(1):e004968. doi: 10.1161/JAHA.116.004968.
3
Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events.平滑肌细胞特异性Tgfbr1缺陷通过刺激多种信号事件促进主动脉瘤形成。
Sci Rep. 2016 Oct 14;6:35444. doi: 10.1038/srep35444.
4
Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.转录因子TBX4调节肌成纤维细胞的积聚和肺纤维化。
J Clin Invest. 2016 Sep 1;126(9):3626. doi: 10.1172/JCI89968. Epub 2016 Aug 22.
5
An evaluation of the effect of an angiotensin-converting enzyme inhibitor on the growth rate of small abdominal aortic aneurysms: a randomized placebo-controlled trial (AARDVARK).血管紧张素转换酶抑制剂对小腹主动脉瘤生长速率影响的评估：一项随机安慰剂对照试验（AARDVARK）
Eur Heart J. 2016 Nov 7;37(42):3213-3221. doi: 10.1093/eurheartj/ehw257. Epub 2016 Jul 1.
6
TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions.转化生长因子-β中和作用增强了血管紧张素II诱导的胸腹部主动脉破裂和动脉瘤形成。
PLoS One. 2016 Apr 22;11(4):e0153811. doi: 10.1371/journal.pone.0153811. eCollection 2016.
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Ascending Aortic Aneurysm in Angiotensin II-Infused Mice: Formation, Progression, and the Role of Focal Dissections.血管紧张素 II 输注小鼠升主动脉瘤的形成、进展及局灶性夹层的作用
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Incidence, severity, mortality, and confounding factors for dissecting AAA detection in angiotensin II-infused mice: a meta-analysis.血管紧张素 II 输注小鼠夹层 AAA 检测的发病率、严重程度、死亡率和混杂因素的荟萃分析。
Cardiovasc Res. 2015 Oct 1;108(1):159-70. doi: 10.1093/cvr/cvv215. Epub 2015 Aug 24.
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Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II-Induced Medial Hyperplasia in the Ascending Aorta.成纤维细胞血管紧张素II 1a型受体促成升主动脉中血管紧张素II诱导的中层增生。
Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1995-2002. doi: 10.1161/ATVBAHA.115.305995. Epub 2015 Jul 9.