Jilka S M, Joyner M J, Nittolo J M, Kalis J K, Taylor J A, Lohman T G, Wilmore J H
Department of Exercise and Sport Sciences, University of Arizona, Tucson 85721.
Med Sci Sports Exerc. 1988 Dec;20(6):570-3.
Conflicting data on the alterations in the maximal exercise response to beta blockade (BB) may be the result of differences in the length of time the subject has been on medication, i.e., hours vs days. The purpose of this study was to examine maximal exercise responses during acute and chronic administration of BB. Twenty-eight healthy males, 14 untrained (UT) and 14 involved in a personal training regimen (TR), performed maximal treadmill tests after 1 d and 9 d under three double-blind, randomized conditions: a placebo (PLAC), propranolol (PROP) 80 mg b.i.d., and atenolol (ATEN) 100 mg o.d. Maximal heart rate (HR), oxygen consumption (VO2), ventilation (VE), and treadmill time were significantly reduced by PROP and ATEN after an acute and chronic dose when compared to PLAC (P less than 0.05) in both groups of subjects. Maximal HR was decreased more after 1 d of BB than after 9 d of BB with both PROP and ATEN in the UT subjects and with PROP only in the TR group. VO2max, VEmax, and treadmill time were also less attenuated after 9 d of BB; however, this trend did not reach statistical significance. The nonselective beta blocker, PROP, caused greater reductions in VO2max compared to the selective beta blocker, ATEN, in both groups of subjects. These data indicate that, other than a small change in maximal HR, there is no difference in the exercise response to acute and chronic BB in normal and highly conditioned individuals.
关于β受体阻滞剂（BB）对最大运动反应改变的相互矛盾的数据，可能是由于受试者用药时间长短不同所致，即数小时与数天的差异。本研究的目的是检查急性和慢性给予BB期间的最大运动反应。28名健康男性，14名未经训练（UT）和14名参与个人训练方案（TR），在三种双盲、随机条件下，分别于1天和9天后进行最大跑步机测试：安慰剂（PLAC）、普萘洛尔（PROP）80mg每日两次、阿替洛尔（ATEN）100mg每日一次。与PLAC相比，在急性和慢性给药后，PROP和ATEN使两组受试者的最大心率（HR）、耗氧量（VO2）、通气量（VE）和跑步机运动时间显著降低（P<0.05）。在UT组受试者中，使用PROP和ATEN时，BB治疗1天后的最大HR降低幅度大于9天后，而在TR组中仅使用PROP时也是如此。BB治疗9天后，VO2max、VEmax和跑步机运动时间的衰减也较小；然而，这一趋势未达到统计学显著性。在两组受试者中，非选择性β受体阻滞剂PROP与选择性β受体阻滞剂ATEN相比，导致VO2max的降低幅度更大。这些数据表明，除了最大HR有微小变化外，正常和高度适应个体对急性和慢性BB的运动反应没有差异。
