Wonisch Manfred, Hofmann Peter, Fruhwald Friedrich M, Hoedl Ronald, Schwaberger Günther, Pokan Rochus, von Duvillard Serge P, Klein Werner
Department of Sport Science, Karl-Franzens-University, Graz, Austria.
Eur J Appl Physiol. 2002 May;87(1):66-71. doi: 10.1007/s00421-002-0595-3. Epub 2002 Mar 22.
The aim of this study was to compare the effect of taking bisoprolol (B), a highly beta(1)-selective adrenoceptor antagonist to that of a placebo (P) on maximal lactate steady state (MLSS), which reflects the transition from oxidative to partially anaerobic metabolism. Ten healthy male subjects [mean (SD) age 23 (3) years, height 181 (6) cm, body mass 76 (6) kg] randomly received oral P or B (5 mg x day(-1)) for 2 weeks using a double-blind crossover design. In the 2nd week, the subjects performed an incremental cycle ergometer test until exhaustion to determine the second blood lactate turn point (LTP(2)). At regular intervals of 24-48 h, the subjects performed 2-3 steady-state tests to determine the MLSS. During the incremental exercise, heart rate (HR) was significantly lower at rest (15 beats x min(-1)), at LTP(2) (23 beats x min(-1)) and at maximal power output (19 beats x min(-1)) when taking B compared to P. Oxygen pulse was significantly higher taking B and no significant differences were observed for any of the respiratory gas exchange measurements (RGEM) (oxygen consumption, carbon dioxide production, minute ventilation, respiratory exchange ratio), exercise intensity or blood lactate concentration (LA) at baseline, at LTP(2) and at maximal power output. During exercise at constant intensity, significant differences between B and P were found for HR [148 (12) compared to 176 (11) beats x min(-1)] and oxygen pulse [21.8 (1.9) compared to 19.2 (1.6) ml] at MLSS. No difference was found for exercise intensity [216 (18) compared to 218 (18) W], for RGEM, LA [5.3 (1.1) compared to 4.8 (1.5) mmol x l(-1)] and ratings of perceived exertion [18.1 (1.6) compared to 17.4 (1.7)] for B and P at MLSS. In both, the power output at LTP(2) was slightly higher than power output at MLSS (within an intensity step). Commonly measured cardiorespiratory and subjective variables determined during treatment with 5 mg bisoprolol can be used for testing cardiorespiratory fitness and for prescription of training intensity.
本研究的目的是比较服用比索洛尔（B）（一种高选择性β₁肾上腺素能受体拮抗剂）与服用安慰剂（P）对最大乳酸稳态（MLSS）的影响，MLSS反映了从氧化代谢到部分无氧代谢的转变。10名健康男性受试者[平均（标准差）年龄23（3）岁，身高181（6）厘米，体重76（6）千克]采用双盲交叉设计，随机口服P或B（5毫克×天⁻¹），为期2周。在第2周，受试者进行递增式蹬车试验直至力竭，以确定第二个血乳酸拐点（LTP₂）。每隔24 - 48小时，受试者进行2 - 3次稳态试验以确定MLSS。在递增运动期间，与服用P相比，服用B时静息心率（HR）显著降低（15次×分钟⁻¹）、LTP₂时（23次×分钟⁻¹）以及最大功率输出时（19次×分钟⁻¹）。服用B时氧脉搏显著升高，在基线、LTP₂和最大功率输出时，任何呼吸气体交换测量指标（RGEM）（耗氧量、二氧化碳产生量、分钟通气量、呼吸交换率）、运动强度或血乳酸浓度（LA）均未观察到显著差异。在恒定强度运动期间，在MLSS时，B和P在HR[148（12）次与176（11）次×分钟⁻¹]和氧脉搏[21.8（1.9）毫升与19.2（1.6）毫升]方面存在显著差异。在MLSS时，B和P在运动强度[216（18）瓦与218（18）瓦]、RGEM、LA[5.3（1.1）毫摩尔×升⁻¹与4.8（1.5）毫摩尔×升⁻¹]以及主观用力感觉评分[18.1（1.6）与17.4（1.7）]方面未发现差异。在两者中，LTP₂时的功率输出略高于MLSS时的功率输出（在一个强度级别内）。在使用5毫克比索洛尔治疗期间测定的常见心肺和主观变量可用于测试心肺适能和规定训练强度。
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