Ghadirian E, Kongshavn P A
Montreal General Hospital Research Institute, McGill University, Montreal, Quebec, Canada.
Microb Pathog. 1987 Apr;2(4):241-8. doi: 10.1016/0882-4010(87)90122-7.
Intestinal amoebiasis caused by Entamoeba histolytica trophozoites in mice is accompanied by a depression in the ability of this host to develop an immune response to sheep red blood cells. The number of splenic plaque-forming cells was reduced in mice inoculated intracecally with 2.5 x 10(5) trophozoites at 15, 25, 40, 65 and 75 days after infection when compared with non-infected mice. It was found that there was no significant difference between the spleen weight of the infected and non-infected control animals at 5 and 10 days following infection. However, a significant increase in spleen weight was observed by 15 days of infection and the spleens remained enlarged until termination of the experiment at 75 days. Thus, there was an inverse correlation between the PFC response and the spleen weight of infected animals.
由溶组织内阿米巴滋养体引起的小鼠肠道阿米巴病，伴随着宿主对绵羊红细胞产生免疫反应的能力下降。与未感染小鼠相比，在感染后第15、25、40、65和75天，经盲肠接种2.5×10⁵个滋养体的小鼠脾脏中形成斑块的细胞数量减少。结果发现，感染后5天和10天，感染组和未感染对照组动物的脾脏重量没有显著差异。然而，在感染15天时观察到脾脏重量显著增加，并且脾脏一直肿大，直到75天实验结束。因此，感染动物的PFC反应与脾脏重量之间呈负相关。
