Ghadirian E, Kongshavn P A
Parasite Immunol. 1984 Jul;6(4):349-60. doi: 10.1111/j.1365-3024.1984.tb00807.x.
Genetic susceptibility to Entamoeba histolytica infection in nine inbred strains and one outbred strain of mice was studied. The number of E. histolytica trophozoites in the ceca of the mice was examined 5 days after intracecal inoculation of axenic amoebae. C3H/HeCr, BALB/c, NZB/BIN, B10.A, DBA/2 and C57BL/6 were susceptible whereas A/J, CE, DBA/1 and CD-1 mouse strains were relatively resistant. Examination of F1 hybrid animals derived from susceptible B10.A and resistant A/J strains of mice showed that susceptibility was dominant over resistance. Segregation analysis of backcross and F2 progeny derived from the same progenitor strains is compatible with the hypothesis that susceptibility to E. histolytica infection in mice is controlled by a single, dominant gene which has been designated Enh. No association was found between the H-2 haplotype and the trait of susceptibility to amoebiasis, indicating that the major histocompatibility complex does not play a major role in regulating the early phase of the response to infection with E. histolytica.
研究了9个近交系和1个远交系小鼠对溶组织内阿米巴感染的遗传易感性。在无菌接种阿米巴后5天，检查小鼠盲肠内溶组织内阿米巴滋养体的数量。C3H/HeCr、BALB/c、NZB/BIN、B10.A、DBA/2和C57BL/6易感，而A/J、CE、DBA/1和CD-1小鼠品系相对抗性。对来自易感的B10.A和抗性的A/J小鼠品系的F1杂交动物的检查表明，易感性对抗性呈显性。对来自相同亲本品系的回交和F2后代的分离分析与以下假设相符：小鼠对溶组织内阿米巴感染的易感性由一个单一的显性基因控制，该基因已被命名为Enh。未发现H-2单倍型与阿米巴病易感性特征之间存在关联，这表明主要组织相容性复合体在调节对溶组织内阿米巴感染反应的早期阶段不发挥主要作用。
