Takano-Yamamoto Teruko, Sasaki Kiyo, Fatemeh Goudarzi, Fukunaga Tomohiro, Seiryu Masahiro, Daimaruya Takayoshi, Takeshita Nobuo, Kamioka Hiroshi, Adachi Taiji, Ida Hiroto, Mayama Atsushi
Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Miyagi, 980-8575, Japan.
Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Hokkaido, 060-8586, Japan.
Sci Rep. 2017 Oct 25;7(1):13969. doi: 10.1038/s41598-017-13541-7.
Several recent prospective clinical trials have investigated the effect of supplementary vibration applied with fixed appliances in an attempt to accelerate tooth movement and shorten the duration of orthodontic treatment. Among them, some studies reported an increase in the rate of tooth movement, but others did not. This technique is still controversial, and the underlying cellular and molecular mechanisms remain unclear. In the present study, we developed a new vibration device for a tooth movement model in rats, and investigated the efficacy and safety of the device when used with fixed appliances. The most effective level of supplementary vibration to accelerate tooth movement stimulated by a continuous static force was 3 gf at 70 Hz for 3 minutes once a week. Furthermore, at this optimum-magnitude, high-frequency vibration could synergistically enhance osteoclastogenesis and osteoclast function via NF-κB activation, leading to alveolar bone resorption and finally, accelerated tooth movement, but only when a static force was continuously applied to the teeth. These findings contribute to a better understanding of the mechanism by which optimum-magnitude high-frequency vibration accelerates tooth movement, and may lead to novel approaches for the safe and effective treatment of malocclusion.
最近的几项前瞻性临床试验研究了在固定矫治器上施加辅助振动对加速牙齿移动和缩短正畸治疗疗程的效果。其中，一些研究报告称牙齿移动速率有所增加，但其他研究则未发现此现象。该技术仍存在争议，其潜在的细胞和分子机制尚不清楚。在本研究中，我们为大鼠牙齿移动模型开发了一种新型振动装置，并研究了该装置与固定矫治器联合使用时的疗效和安全性。在连续静力作用下，加速牙齿移动的最有效辅助振动水平为每周一次，70赫兹、3克力、持续3分钟。此外，在此最佳强度下，高频振动可通过激活核因子κB协同增强破骨细胞生成和破骨细胞功能，导致牙槽骨吸收，最终加速牙齿移动，但前提是需持续对牙齿施加静力。这些发现有助于更好地理解最佳强度高频振动加速牙齿移动的机制，并可能为安全有效地治疗错牙合畸形带来新方法。
