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复发性低流量型阴茎异常勃起的预防:实验性肉毒杆菌神经毒素注射至坐骨海绵体肌

[Prophylaxis of recurring low-flow priapism : Experimental botulinum neurotoxin injection into the ischiocavernosus muscle].

作者信息

Reichel G, Stenner A

机构信息

Kompetenzzentrum für Bewegungsstörungen, Paracelsusklinik Zwickau, Werdauer Str. 68, 08060, Zwickau, Deutschland.

Neurologische Fachabteilung des MVZ, Paracelsusklinik Zwickau, Zwickau, Deutschland.

出版信息

Urologe A. 2018 Jan;57(1):40-43. doi: 10.1007/s00120-017-0534-x.

DOI:10.1007/s00120-017-0534-x
PMID:29071397
Abstract

The treatment of recurring low-flow priapism with the usual medications is still unsatisfactory. The case of an otherwise healthy young man experiencing low-flow priapism at the age of 31 is presented. A reason for his condition could not be identified. Over the course of several months, he required emergency urological treatment more than ten times. Treatment with cyproterone acetate (Androcur® 50 mg/day) stopped the spontaneous erections, but resulted in erectile impotence, reduced motivation, decreased interest in sex, weight gain of 10 kg, breast enlargement combined with touch sensitivity on both sides, and hair loss on both legs. In addition, the patient complained about painful cramps in his pelvic muscles. After appropriate explanations he agreed to try botulinum neurotoxin injections into both ischiocavernosus muscles. The objective was to reduce muscle tone in order to improve venous drainage of blood from the penis. The latest relapse of priapism occurred more than 6 months ago.

摘要

使用常规药物治疗复发性低流量阴茎异常勃起仍不尽人意。本文介绍了一名31岁身体健康的年轻男子出现低流量阴茎异常勃起的病例。其病因无法确定。在几个月的时间里,他需要接受十多次紧急泌尿外科治疗。使用醋酸环丙孕酮(Androcur® 50毫克/天)治疗可停止自发性勃起,但导致勃起功能障碍、动力下降、对性的兴趣降低、体重增加10公斤、双侧乳房增大并伴有触痛、双腿脱发。此外,患者抱怨骨盆肌肉疼痛性痉挛。在进行适当解释后,他同意尝试向双侧坐骨海绵体肌注射肉毒杆菌神经毒素。目的是降低肌肉张力,以改善阴茎的静脉血液引流。阴茎异常勃起的最新一次复发发生在6个多月前。

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[Prophylaxis of recurring low-flow priapism : Experimental botulinum neurotoxin injection into the ischiocavernosus muscle].复发性低流量型阴茎异常勃起的预防:实验性肉毒杆菌神经毒素注射至坐骨海绵体肌
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本文引用的文献

1
Clinical Management of Priapism: A Review.阴茎异常勃起的临床管理:综述
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[Priapism: Current diagnostics and therapy].[阴茎异常勃起:当前的诊断与治疗]
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Anatomy and physiology of genital organs - men.男性生殖器官的解剖学与生理学
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