Zhou Yin, Zhu Jun, Li Lian-Bo, He Tian-Feng, Chen Xiao-Yi, Zheng Yong-Yao, Chen Yun-Fei
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
College of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.
Zhen Ci Yan Jiu. 2016 Oct 25;41(5):440-6.
To compare the effects between electroacupuncture (EA) plus western medicine and simple western medicine in improving clinical symptoms and local joint function of rheumatoid arthritis (RA) patients with deficiency of Liver and Kidney.
A total of 68 RA patients of deficiency of Liver and Kidney were equally randomized into EA+medication group and medication group (=34 in each group). Both groups were given once-a-week methotrexate (7.5 mg/time) and once-a-day leflunomide (10 mg/time), while EA+medication group was additionally treated by EA at bilateral Ganshu (BL 18), Shenshu (BL 23), Xuanzhong (GB 39), Zusanli (ST 36), Taichong (LR 3), Hegu (LI 4) 3 times/week. The treatment lasted for 12 weeks. The visual analogue scale (VAS, for assessing rest pain), swollen joint count (SJC), tender joint count (TJC), patient's global assessment (PGA), physician's global assessment (PhGA), traditional Chinese medicine (TCM) symptom scoring, 28 joints activity index (disease activity score, DAS 28), American College of Rheumatology 20 (ACR 20, i.e. 20% of clinical improving rate), and health assessment questionnaire (HAQ) were assessed and erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP) levels were examined for comparison.
Statistical differences were observed in before-after-treatment comparisons in both groups in reducing rest pain, SJC, TJC, serum CRP content, PGA and PhGA, HAQ scoring and DAS 28 (<0.05, <0.01). The ESR in the medication group and TCM symptom scoring of the EA+medication group were also significantly decreased after the treatment (<0.05).The effects of the EA+medication group were superior to those of the medication group in reducing rest pain, SJC, TJC, TCM symptom and HAQ score, and the total effetive rate (<0.05,90.9% vs 66.67%). Adverse reactions as pharyngeal obstruction sensation, anorexia, abdominal distension, etc. can be reduced by EA therapy coordinated with western medicine.
EA is effective in relieving symptom and joint function in RA patients with deficiency of Liver and Kidney.
比较电针联合西药与单纯西药对肝肾亏虚型类风湿关节炎（RA）患者临床症状及局部关节功能的改善作用。
将68例肝肾亏虚型RA患者随机分为电针+药物组和药物组，每组34例。两组均给予每周1次甲氨蝶呤（7.5mg/次）及每日1次来氟米特（10mg/次），电针+药物组在此基础上，加用电针针刺双侧肝俞（BL18）、肾俞（BL23）、悬钟（GB39）、足三里（ST36）、太冲（LR3）、合谷（LI4），每周3次。治疗12周。观察视觉模拟评分法（VAS，评估静息痛）、肿胀关节计数（SJC）、压痛关节计数（TJC）、患者整体评估（PGA）、医生整体评估（PhGA）、中医症状评分、28个关节活动指数（疾病活动评分，DAS28）、美国风湿病学会20%改善标准（ACR20，即临床改善率达20%）及健康评估问卷（HAQ），并检测红细胞沉降率（ESR）、血清C反应蛋白（CRP）水平进行比较。
两组治疗前后在减轻静息痛、SJC、TJC、血清CRP含量、PGA、PhGA、HAQ评分及DAS28方面比较，差异有统计学意义（P<0.05，P<0.01）。药物组ESR及电针+药物组中医症状评分治疗后亦显著降低（P<0.05）。电针+药物组在减轻静息痛、SJC、TJC、中医症状及HAQ评分方面疗效优于药物组，总有效率比较差异有统计学意义（P<0.05，90.9%对66.67%）。电针配合西药治疗可减少咽部梗阻感、厌食、腹胀等不良反应。
电针能有效改善肝肾亏虚型RA患者的症状及关节功能。
