Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sackler Faculty of Medicine, Tel Aviv University, Israel.
Future Oncol. 2018 Jan;14(2):111-122. doi: 10.2217/fon-2017-0393. Epub 2017 Oct 26.
Neuroendocrine tumors (NETs) are rare neoplasms that emerge mainly from the GI tract, pancreas and respiratory tract. The incidence of NETs has increased more than sixfold in the last decades. NETs typically express somatostatin receptors on their cell surface, which can be targeted by 'cold' somatostatin analogs for therapy or by 'hot' radiolabeled somatostatin analogs for tumor localization and treatment. 68-Gallium-DOTA peptides (DOTATATE, DOTATOC, DOTANOC) positron emission tomography/computed tomography is a highly accurate imaging modality for NETs that has been found to be more sensitive for NET detection than other imaging modalities. In the current review, we will discuss the clinical utility of 68-Gallium-DOTATATE positron emission tomography/computed tomography for the diagnosis and management of patients with NETs.
神经内分泌肿瘤（NETs）是一种罕见的肿瘤，主要来源于胃肠道、胰腺和呼吸道。在过去几十年中，NETs 的发病率增加了六倍以上。NETs 通常在其细胞表面表达生长抑素受体，这些受体可被“冷”生长抑素类似物靶向用于治疗，或被“热”放射性标记生长抑素类似物靶向用于肿瘤定位和治疗。68-镓-DOTA 肽（DOTATATE、DOTATOC、DOTANOC）正电子发射断层扫描/计算机断层扫描是一种高度准确的 NETs 成像方式，其对 NETs 的检测灵敏度高于其他成像方式。在本综述中，我们将讨论 68-镓-DOTATATE 正电子发射断层扫描/计算机断层扫描在 NETs 患者的诊断和管理中的临床应用。
