a Laboratory of Animal Physiology, Sciences Faculty of Sfax , University of Sfax , Sfax , Tunisia.
b Anatomopathology Laboratory , CHU Habib Bourguiba, Sfax University , Sfax , Tunisia.
Arch Physiol Biochem. 2018 Jul;124(3):237-246. doi: 10.1080/13813455.2017.1392579. Epub 2017 Oct 26.
Barium (Ba) may induce oxidative stress leading to tissues injury.
Our study investigated the therapeutic efficiency of zinc (Zn) and selenium (Se) against neurotoxicity induced by Ba in adult rats and their progeny.
Pregnant rats are exposed either to Ba (67 ppm), Ba + Zn, Ba + S or to only Zn and Se.
In Ba-treated rats, there was an increase of MDA, HO, AOPP levels and SOD activity in the cerebellum of dams and their pups, a decrease in GPx, CAT, AChE, NaK-ATPase and Mg-ATPase activities, GSH and NPSH levels. These changes were confirmed by histological damages. Co-administration of Zn or Se to Ba-treated rats ameliorated the biochemical and histological aspects.
Our results revealed that Zn and Se have shown promising effects against Ba toxicity in the cerebellum of adult rats and their suckling pups.
钡（Ba）可能会诱导氧化应激，导致组织损伤。
本研究旨在探讨锌（Zn）和硒（Se）对成年大鼠及其后代因钡引起的神经毒性的治疗效果。
将怀孕的大鼠暴露于钡（67ppm）、钡+锌、钡+硒或仅锌和硒中。
在接受钡处理的大鼠中，其母鼠及其幼崽的小脑丙二醛（MDA）、羟基自由基（HO）、过氧亚硝酸盐（AOPP）水平和超氧化物歧化酶（SOD）活性升高，谷胱甘肽过氧化物酶（GPx）、过氧化氢酶（CAT）、乙酰胆碱酯酶（AChE）、钠钾三磷酸腺苷酶（NaK-ATPase）和镁三磷酸腺苷酶（Mg-ATPase）活性、还原型谷胱甘肽（GSH）和非蛋白巯基（NPSH）水平降低。这些变化通过组织学损伤得到了证实。将锌或硒与钡处理的大鼠共同给药，改善了其小脑的生化和组织学方面的状况。
我们的结果表明，锌和硒对成年大鼠及其幼崽的小脑的钡毒性具有显著的治疗效果。
