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尼日利亚恶性乳腺癌的贝叶斯推断:马尔可夫链蒙特卡罗收敛诊断

Bayesian Inference on Malignant Breast Cancer in Nigeria: A Diagnosis of MCMC Convergence.

作者信息

Ogunsakin Ropo Ebenezer, Siaka Lougue

机构信息

Statistics Department, University of Kwa Zulu Natal, Westville Campus, Durban, South Africa. Email: 215082165@ stu.ukzn.ac.za

出版信息

Asian Pac J Cancer Prev. 2017 Oct 26;18(10):2709-2716. doi: 10.22034/APJCP.2017.18.10.2709.

DOI:10.22034/APJCP.2017.18.10.2709
PMID:29072396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5747394/
Abstract

Background: There has been no previous study to classify malignant breast tumor in details based on Markov Chain Monte Carlo (MCMC) convergence in Western, Nigeria. This study therefore aims to profile patients living with benign and malignant breast tumor in two different hospitals among women of Western Nigeria, with a focus on prognostic factors and MCMC convergence. Materials and Methods: A hospital-based record was used to identify prognostic factors for malignant breast cancer among women of Western Nigeria. This paper describes Bayesian inference and demonstrates its usage to estimation of parameters of the logistic regression via Markov Chain Monte Carlo (MCMC) algorithm. The result of the Bayesian approach is compared with the classical statistics. Results: The mean age of the respondents was 42.2 ±16.6 years with 52% of the women aged between 35-49 years. The results of both techniques suggest that age and women with at least high school education have a significantly higher risk of being diagnosed with malignant breast tumors than benign breast tumors. The results also indicate a reduction of standard errors is associated with the coefficients obtained from the Bayesian approach. In addition, simulation result reveal that women with at least high school are 1.3 times more at risk of having malignant breast lesion in western Nigeria compared to benign breast lesion. Conclusion: We concluded that more efforts are required towards creating awareness and advocacy campaigns on how the prevalence of malignant breast lesions can be reduced, especially among women. The application of Bayesian produces precise estimates for modeling malignant breast cancer.

摘要

背景

在尼日利亚西部,此前尚无基于马尔可夫链蒙特卡罗(MCMC)收敛性对恶性乳腺肿瘤进行详细分类的研究。因此,本研究旨在剖析尼日利亚西部女性中两家不同医院的良性和恶性乳腺肿瘤患者情况,重点关注预后因素和MCMC收敛性。

材料与方法

采用基于医院的记录来确定尼日利亚西部女性中恶性乳腺癌的预后因素。本文描述了贝叶斯推断,并展示了其通过马尔可夫链蒙特卡罗(MCMC)算法在逻辑回归参数估计中的应用。将贝叶斯方法的结果与经典统计方法进行比较。

结果

受访者的平均年龄为42.2±16.6岁,其中52%的女性年龄在35 - 49岁之间。两种技术的结果均表明,年龄较大以及至少受过高中教育的女性被诊断为恶性乳腺肿瘤的风险显著高于良性乳腺肿瘤。结果还表明,贝叶斯方法获得的系数与标准误差的降低相关。此外,模拟结果显示,在尼日利亚西部,至少受过高中教育的女性患恶性乳腺病变的风险是良性乳腺病变的1.3倍。

结论

我们得出结论,需要做出更多努力,开展关于如何降低恶性乳腺病变患病率的宣传和倡导活动,尤其是针对女性。贝叶斯方法的应用为恶性乳腺癌建模提供了精确估计。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b19/5747394/05903a066737/APJCP-18-2709-g029.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b19/5747394/9fb405a128d3/APJCP-18-2709-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b19/5747394/6cb6f3c54709/APJCP-18-2709-g027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b19/5747394/ba06d2ed8c75/APJCP-18-2709-g028.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b19/5747394/05903a066737/APJCP-18-2709-g029.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b19/5747394/9fb405a128d3/APJCP-18-2709-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b19/5747394/6cb6f3c54709/APJCP-18-2709-g027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b19/5747394/ba06d2ed8c75/APJCP-18-2709-g028.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b19/5747394/05903a066737/APJCP-18-2709-g029.jpg

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