Department for Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Košice, Slovakia.
Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia.
Molecules. 2017 Oct 26;22(11):1818. doi: 10.3390/molecules22111818.
It is now suggested that the inhibition of biological programs that are associated with the tumor microenvironment may be critical to the diagnostics, prevention and treatment of cancer. On the other hand, a suitable wound microenvironment would accelerate tissue repair and prevent extensive scar formation. In the present review paper, we define key signaling molecules (growth factors, cytokines, chemokines, and galectins) involved in the formation of the tumor microenvironment that decrease overall survival and increase drug resistance in cancer suffering patients. Additional attention will also be given to show whether targeted modulation of these regulators promote tissue regeneration and wound management. Whole-genome transcriptome profiling, in vitro and animal experiments revealed that interleukin 6, interleukin 8, chemokine (C-X-C motif) ligand 1, galectin-1, and selected proteins of the extracellular matrix (e.g., fibronectin) do have similar regulation during wound healing and tumor growth. Published data demonstrate remarkable similarities between the tumor and wound microenvironments. Therefore, tailor made manipulation of cancer stroma can have important therapeutic consequences. Moreover, better understanding of cancer cell-stroma interaction can help to improve wound healing by supporting granulation tissue formation and process of reepithelization of extensive and chronic wounds as well as prevention of hypertrophic scars and formation of keloids.
现在有人提出，抑制与肿瘤微环境相关的生物程序可能对癌症的诊断、预防和治疗至关重要。另一方面，合适的创面微环境将加速组织修复并防止广泛的瘢痕形成。在本综述论文中，我们定义了参与肿瘤微环境形成的关键信号分子（生长因子、细胞因子、趋化因子和半乳糖凝集素），这些信号分子会降低癌症患者的总体生存率并增加其耐药性。此外，我们还将关注这些调节剂的靶向调节是否能促进组织再生和创面管理。全基因组转录组谱分析、体外和动物实验表明，白细胞介素 6、白细胞介素 8、趋化因子（C-X-C 基序）配体 1、半乳糖凝集素 1 和细胞外基质中的选定蛋白（例如纤维连接蛋白）在创面愈合和肿瘤生长过程中具有相似的调节作用。已发表的数据表明，肿瘤微环境和创面微环境之间存在显著的相似性。因此，针对肿瘤基质的定制操作可能会产生重要的治疗效果。此外，更好地了解癌细胞-基质相互作用有助于通过支持肉芽组织形成和广泛慢性创面的上皮化过程以及预防增生性瘢痕和瘢痕疙瘩形成来改善创面愈合。
