Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Mech Ageing Dev. 2018 Jun;172:51-58. doi: 10.1016/j.mad.2017.11.004. Epub 2017 Nov 11.
Wound healing is one of the most complex processes in multicellular organisms, involving numerous intra- and intercellular signalling pathways in various cell types. It involves extensive communication between the cellular constituents of diverse skin compartments and its extracellular matrix. Miscommunication during healing may have two distinct damaging consequences: the development of a chronic wound or the formation of a hypertrophic scar/keloid. Chronic wounds are defined as barrier defects that have not proceeded through orderly and timely reparation to regain structural and functional integrity. Several growth factors are involved in wound healing, of which transforming growth factor beta (TGFβ) is of particular importance for all phases of this procedure. It exerts pleiotropic effects on wound healing by regulating cell proliferation, differentiation, extracellular matrix production, and modulating the immune response. In this review we are presenting the role of TGFβ in physiological and pathological wound healing. We show that the context-dependent nature of the TGFβ signaling pathways on wound healing is the biggest challenge in order to gain a therapeutically applicable comprehensive knowledge of their specific involvement in chronic wounds.
伤口愈合是多细胞生物中最复杂的过程之一，涉及各种细胞类型中众多的细胞内和细胞间信号通路。它涉及不同皮肤区域的细胞成分及其细胞外基质之间的广泛通讯。愈合过程中的通讯错误可能有两个截然不同的破坏性后果：慢性伤口的形成或增生性瘢痕/瘢痕疙瘩的形成。慢性伤口被定义为屏障缺陷，未能通过有序和及时的修复来恢复结构和功能的完整性。几种生长因子参与伤口愈合，其中转化生长因子β（TGFβ）对于该过程的所有阶段都特别重要。它通过调节细胞增殖、分化、细胞外基质的产生和调节免疫反应，对伤口愈合发挥多效性作用。在这篇综述中，我们介绍了 TGFβ 在生理和病理伤口愈合中的作用。我们表明，TGFβ 信号通路在伤口愈合中的上下文依赖性是获得其在慢性伤口中特定参与的治疗性应用的全面知识的最大挑战。
