Sheng Yujie, Sutton Mark J, Ebrahimi Kourosh H
Institute of Pharmaceutical Science, King's College London, London, UK.
UK Health Security Agency, UK.
Chem Commun (Camb). 2025 Aug 18. doi: 10.1039/d5cc03592a.
There is a growing interest in developing one-health "plug and play" platforms for making different therapeutics/prophylactics to target various biological entities such as viruses, cancer cells, or bacteria. Such a platform could benefit from advances in artificial intelligence (AI) for sustainable manufacturing. In this respect, naturally occurring protein nanocages, such as iron-storage protein ferritin, are emerging as ideal candidates for various applications in nanomedicine. However, the spontaneous self-assembly of these naturally occurring nanocages has been a bottleneck for their application as a one-health "plug and play" platform. In this review, we will take a fresh look at the application of natural protein nanocages in nanomedicine by discussing our current understanding of their self-assembly process. We highlight our recent progress in engineering ferritin subunits to create a one-health "plug and play" platform technology to develop various therapeutic or prophylactic nanomedicines. We will discuss the advantages of this technology, its implications for understanding nanocage assembly, and potential future application areas.
人们对开发用于制造针对病毒、癌细胞或细菌等各种生物实体的不同治疗剂/预防剂的“即插即用”的一体化健康平台的兴趣与日俱增。这样的平台可以受益于人工智能（AI）在可持续制造方面的进展。在这方面，天然存在的蛋白质纳米笼，如铁储存蛋白铁蛋白，正成为纳米医学各种应用的理想候选者。然而，这些天然存在的纳米笼的自发自组装一直是其作为一体化健康“即插即用”平台应用的瓶颈。在这篇综述中，我们将通过讨论我们目前对其自组装过程的理解，重新审视天然蛋白质纳米笼在纳米医学中的应用。我们强调了我们在工程化铁蛋白亚基以创建一体化健康“即插即用”平台技术以开发各种治疗性或预防性纳米药物方面的最新进展。我们将讨论这项技术的优势、其对理解纳米笼组装的意义以及潜在的未来应用领域。
