Hathuc Vivian M, Hristov Alexandra C, Smith Lauren B
From the Sections of Hematopathology (Drs Hathuc and Smith) and Dermatopathology (Dr Hristov) in the Department of Pathology, University of Michigan Medical Center, Ann Arbor.
Arch Pathol Lab Med. 2017 Nov;141(11):1469-1475. doi: 10.5858/arpa.2017-0230-RA.
Primary cutaneous acral CD8 T-cell lymphoma is a new provisional entity in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. This is a challenging diagnosis because of its rarity, as well as its morphologic and immunophenotypic overlap with other CD8 cytotoxic lymphoid proliferations. Appropriate classification of this entity is crucial because of its indolent clinical behavior compared with other CD8 T-cell lymphomas. Knowledge of the clinical setting, sites of involvement, and morphologic features can aid in correct diagnosis. Here, we review the clinical and pathologic features of primary cutaneous acral CD8 T-cell lymphoma with an emphasis on the differential diagnosis among other C8 T-cell lymphomas.
原发性皮肤肢端CD8 T细胞淋巴瘤是2016年世界卫生组织淋巴肿瘤分类修订版中的一个新的暂定实体。由于其罕见性，以及在形态学和免疫表型上与其他CD8细胞毒性淋巴增殖性疾病存在重叠，因此这是一个具有挑战性的诊断。由于与其他CD8 T细胞淋巴瘤相比，该实体具有惰性的临床行为，因此对其进行恰当分类至关重要。了解临床背景、受累部位和形态学特征有助于正确诊断。在此，我们回顾原发性皮肤肢端CD8 T细胞淋巴瘤的临床和病理特征，重点是与其他CD8 T细胞淋巴瘤的鉴别诊断。
