Kutuk Meryem Ozlem, Guler Gulen, Tufan Ali Evren, Kutuk Ozgur
Department of Child and Adolescent Psychiatry, Adana Dr. Turgut Noyan Medical and Research Center, Baskent University School of Medicine, Adana, Turkey.
Department of Child and Adolescent Psychiatry, Elazig Mental Health Hospital, Elazig, Turkey.
Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):410-412. doi: 10.9758/cpn.2017.15.4.410.
Our case had hiccups arising in an adolescent with the attention deficit and hyperactivity disorder (ADHD) and conduct disorder (CD) after adding aripiprazole treatment to extended-release methylphenidate. Actually, antipsychotics are also used in the treatment of hiccups, but studies suggest that they can cause hiccups as well. Within 12 hours of taking 2.5 mg aripiprazole added to extended-release methylphenidate at a dose of 54 mg/day, 16-year-old boy began having hiccups in the morning, which lasted after 3-4 hours. As a result, aripiprazole was discontinued and methylphenidate was continued alone because we could not convince the patient to use another additional drug due to this side effect. Subsequently, when his behavior got worsened day by day, his mother administered aripiprazole alone again at the dose of 2.5 mg/day at the weekend and continued treatment because hiccup did not occur again. But when it was administered with methylphenidate on Monday, hiccup started again next morning and lasted one hour at this time. In conclusion, we concluded that concurrent use of methylphenidate and aripiprazole in this adolescent led to hiccups.
我们的病例是一名患有注意力缺陷多动障碍（ADHD）和品行障碍（CD）的青少年，在长效哌甲酯治疗基础上加用阿立哌唑后出现了打嗝症状。实际上，抗精神病药物也用于治疗打嗝，但研究表明它们也可能引发打嗝。在每天服用54毫克长效哌甲酯并加用2.5毫克阿立哌唑后的12小时内，一名16岁男孩早晨开始打嗝，持续了3 - 4小时。结果，由于这种副作用，我们无法说服患者使用其他附加药物，于是停用了阿立哌唑，仅继续使用哌甲酯。随后，当他的行为日益恶化时，他的母亲在周末再次单独给他服用2.5毫克/天的阿立哌唑并继续治疗，因为打嗝没有再次出现。但周一当与哌甲酯一起服用时，第二天早上又开始打嗝，这次持续了一个小时。总之，我们得出结论，该青少年同时使用哌甲酯和阿立哌唑导致了打嗝。
