Zhang Yaoyin, Chen Wei, Chen Junming, Li Mingmei, Huang Yulan, Min Wenjiao
Department of Psychosomatics, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, China.
Front Pharmacol. 2024 Jan 5;14:1284510. doi: 10.3389/fphar.2023.1284510. eCollection 2023.
Aripiprazole, a commonly prescribed antipsychotic, has been rarely associated with the onset of hiccups. This study aims to elucidate the prevalence, risk factors, and management of aripiprazole-induced hiccups. We report a case of aripiprazole-induced hiccups in a 32-year-old male diagnosed with Somatic Symptom Disorder per DSM-5 criteria.A comprehensive literature review was conducted, identifying 29 case reports of aripiprazole-induced hiccups. Patient demographics, dosage, onset and duration of hiccups, and management strategies were analyzed. Aripiprazole-induced hiccups predominantly affected adolescents and middle-aged male patients (86.7%). The majority of hiccups developed within 1-2 days post-prescription (90.9%) and resolved within 1-4 days after discontinuation of aripiprazole. Discontinuation of aripiprazole was the most effective management strategy (51.7%). Co-administration with benzodiazepines was identified as a significant risk factor. The findings suggest that clinicians should be vigilant for the onset of hiccups during the early stages of aripiprazole treatment, especially in male patients and those co-administered with benzodiazepines. Clinicians should be vigilant for hiccups during early aripiprazole treatment. Considering personality and psychological factors is crucial in managing hiccups in psychiatric patients.
阿立哌唑是一种常用的抗精神病药物，很少与打嗝的发作相关。本研究旨在阐明阿立哌唑所致打嗝的患病率、危险因素及处理方法。我们报告一例根据《精神疾病诊断与统计手册》第5版标准诊断为躯体症状障碍的32岁男性患者出现阿立哌唑所致打嗝的病例。进行了全面的文献综述，确定了29例阿立哌唑所致打嗝的病例报告。分析了患者的人口统计学特征、剂量、打嗝的发作及持续时间以及处理策略。阿立哌唑所致打嗝主要影响青少年和中年男性患者（86.7%）。大多数打嗝在开处方后1 - 2天内出现（90.9%），并在停用阿立哌唑后1 - 4天内缓解。停用阿立哌唑是最有效的处理策略（51.7%）。与苯二氮䓬类药物合用被确定为一个显著的危险因素。研究结果表明，临床医生在阿立哌唑治疗的早期阶段应警惕打嗝的发作，尤其是男性患者以及那些同时使用苯二氮䓬类药物的患者。临床医生在阿立哌唑治疗早期应警惕打嗝。在管理精神病患者的打嗝时，考虑人格和心理因素至关重要。
