阿立哌唑联合舍曲林致一名嗅觉参考障碍青少年呃逆：一例报告
Hiccups induced by aripiprazole combined with sertraline in an adolescent with olfactory reference disorder: A case report.
作者信息
Li Zhe, Xiong Zhenzhen, Jiang Xingmei, Li Zhixiong, Yuan Yiwen, Li Xiao
机构信息
Mental Health Center, West China Hospital, Sichuan University, Chengdu, China.
Sichuan Clinical Medical Research Center for Mental Disorders, Chengdu, China.
出版信息
Front Psychiatry. 2022 Jul 25;13:793716. doi: 10.3389/fpsyt.2022.793716. eCollection 2022.
BACKGROUND
Hiccup can cause significant distress to patients and affect medication compliance. Individuals with olfactory reference disorder (ORD) who might develop persistent hiccups when treated with a combination of antidepressant and antipsychotic, leading to significant distress and impairment.
CASE SUMMARY
We report a rare case of an adolescent with ORD who was treated with aripiprazole combined with sertraline and who began to hiccup persistently after 6 days on this treatment. He stopped hiccupping after the aripiprazole had been suspended for 12 h. After discharge, the patient continued on sertraline alone and reported no hiccupping at 1-month follow-up.
CONCLUSION
Clinicians should consider that the combination of aripiprazole and sertraline can induce hiccups during the acute administration period in adolescents with ORD.
背景
呃逆会给患者带来极大困扰，并影响药物治疗依从性。嗅觉参考障碍（ORD）患者在接受抗抑郁药和抗精神病药联合治疗时可能会出现持续性呃逆，从而导致极大困扰和功能损害。
病例摘要
我们报告了一例罕见的ORD青少年病例，该患者接受阿立哌唑联合舍曲林治疗，治疗6天后开始出现持续性呃逆。阿立哌唑停药12小时后呃逆停止。出院后，患者继续单独服用舍曲林，1个月随访时报告无呃逆症状。
结论
临床医生应考虑到，在ORD青少年的急性给药期，阿立哌唑和舍曲林联合使用可能会诱发呃逆。
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