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多种抗精神病药物导致的中性粒细胞减少症，包括鲁拉西酮所致的剂量依赖性中性粒细胞减少症。

Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone.

作者信息

Sood Shabnam

机构信息

Maricopa Integrated Health System/District Medical Group, University of Arizona School of Medicine, Phoenix, AZ, USA.

出版信息

Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):413-415. doi: 10.9758/cpn.2017.15.4.413.

DOI:10.9758/cpn.2017.15.4.413
PMID:29073755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5678486/
Abstract

Antipsychotic-induced agranulocytosis is a significant side effect that is known to occur with most of the antipsychotic medications. It usually resolves once the medications are stopped and patients are able to be switched over to another antipsychotic medication. Lurasidone has not been reported to cause leukopenia and neutropenia. This case report is of a patient with a past history of risperidone induced-aganulocytosis developing dose related leukopenia and neutropenia with lurasidone.

摘要

抗精神病药物所致粒细胞缺乏症是一种严重的副作用，已知大多数抗精神病药物都可引发。一旦停用这些药物，且患者能够换用其他抗精神病药物，该副作用通常会消失。目前尚未有关于鲁拉西酮导致白细胞减少和中性粒细胞减少的报道。本病例报告的患者既往有服用利培酮引发粒细胞缺乏症的病史，此次服用鲁拉西酮后出现了与剂量相关的白细胞减少和中性粒细胞减少。

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Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone.多种抗精神病药物导致的中性粒细胞减少症，包括鲁拉西酮所致的剂量依赖性中性粒细胞减少症。
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本文引用的文献

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Late Onset Agranulocytosis with Clozapine Associated with HLA DR4 Responding to Treatment with Granulocyte Colony-stimulating Factor: A Case Report and Review of Literature.迟发性氯氮平相关性粒细胞缺乏症与 HLA-DR4 相关，用粒细胞集落刺激因子治疗有效：病例报告及文献复习。
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Neuroleptic-induced neutropenia in the elderly.
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Psychopharmacology (Berl). 1989;99 Suppl:S109-12. doi: 10.1007/BF00442573.
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A review of clozapine: an antipsychotic for treatment-resistant schizophrenia.氯氮平综述：一种用于治疗难治性精神分裂症的抗精神病药物。
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