多种抗精神病药物导致的中性粒细胞减少症，包括鲁拉西酮所致的剂量依赖性中性粒细胞减少症。
Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone.
作者信息
Sood Shabnam
机构信息
Maricopa Integrated Health System/District Medical Group, University of Arizona School of Medicine, Phoenix, AZ, USA.
出版信息
Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):413-415. doi: 10.9758/cpn.2017.15.4.413.
Abstract
Antipsychotic-induced agranulocytosis is a significant side effect that is known to occur with most of the antipsychotic medications. It usually resolves once the medications are stopped and patients are able to be switched over to another antipsychotic medication. Lurasidone has not been reported to cause leukopenia and neutropenia. This case report is of a patient with a past history of risperidone induced-aganulocytosis developing dose related leukopenia and neutropenia with lurasidone.
摘要
抗精神病药物所致粒细胞缺乏症是一种严重的副作用，已知大多数抗精神病药物都可引发。一旦停用这些药物，且患者能够换用其他抗精神病药物，该副作用通常会消失。目前尚未有关于鲁拉西酮导致白细胞减少和中性粒细胞减少的报道。本病例报告的患者既往有服用利培酮引发粒细胞缺乏症的病史，此次服用鲁拉西酮后出现了与剂量相关的白细胞减少和中性粒细胞减少。
相似文献
1
Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone.多种抗精神病药物导致的中性粒细胞减少症，包括鲁拉西酮所致的剂量依赖性中性粒细胞减少症。
Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):413-415. doi: 10.9758/cpn.2017.15.4.413.
2
Risperidone-induced retrograde ejaculation and lurasidone may be the alternative.利培酮引起的逆行射精，而鲁拉西酮可能是替代药物。
Ind Psychiatry J. 2019 Jan-Jun;28(1):152-154. doi: 10.4103/ipj.ipj_8_19. Epub 2019 Dec 11.
3
Real-world adherence assessment of lurasidone and other oral atypical antipsychotics among patients with schizophrenia: an administrative claims analysis.精神分裂症患者中鲁拉西酮及其他口服非典型抗精神病药物的真实世界依从性评估：一项行政索赔分析
Curr Med Res Opin. 2017 May;33(5):813-820. doi: 10.1080/03007995.2017.1284656. Epub 2017 Feb 6.
4
Granulocytopenia associated with neuroleptic therapy in a patient with benign familial leukopenia.伴有良性家族性白细胞减少症的患者的神经阻滞剂治疗相关粒细胞减少症。
Int J Psychiatry Clin Pract. 2003;7(4):277-80. doi: 10.1080/13651500310002977.
5
A case with neutropenia related with the use of various atypical antipsychotics.一例与使用各种非典型抗精神病药物相关的中性粒细胞减少症。
Psychiatry Investig. 2013 Dec;10(4):428-31. doi: 10.4306/pi.2013.10.4.428. Epub 2013 Dec 16.
6
Hospitalization risk in bipolar disorder patients treated with lurasidone versus other atypical antipsychotics.双相障碍患者在使用鲁拉西酮与其他非典型抗精神病药物治疗时的住院风险。
Curr Med Res Opin. 2019 Feb;35(2):211-219. doi: 10.1080/03007995.2018.1462787. Epub 2018 Apr 22.
7
Comparative efficacy of typical and atypical antipsychotics as add-on therapy to mood stabilizers in the treatment of acute mania.典型抗精神病药物与非典型抗精神病药物作为心境稳定剂的辅助疗法治疗急性躁狂症的疗效比较
J Clin Psychiatry. 2001 Dec;62(12):975-80. doi: 10.4088/jcp.v62n1210.
8
[Neutropenia in a patient treated with clozapine in combination with other psychotropic drugs].[使用氯氮平联合其他精神药物治疗的患者出现中性粒细胞减少症]
Encephale. 2002 Nov-Dec;28(6 Pt 1):567-9.
9
Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance test.鲁拉西酮（SM-13496），一种新型非典型抗精神病药物，可逆转MK-801在大鼠被动回避试验中引起的学习和记忆障碍。
Eur J Pharmacol. 2007 Oct 31;572(2-3):160-70. doi: 10.1016/j.ejphar.2007.06.058. Epub 2007 Jul 10.
10
Olanzapine-induced and Risperidone-induced Leukopenia: A Case of Synergistic Adverse Reaction?奥氮平所致及利培酮所致白细胞减少症：一例协同不良反应病例？
J Psychiatr Pract. 2018 Mar;24(2):121-124. doi: 10.1097/PRA.0000000000000292.
引用本文的文献
1
Neutropenia in a schizophrenia patient following combined lurasidone and paliperidone therapy: a case report.鲁拉西酮与帕利哌酮联合治疗后精神分裂症患者出现中性粒细胞减少症：一例报告
Postep Psychiatr Neurol. 2023 Sep;32(3):152-155. doi: 10.5114/ppn.2023.132474. Epub 2023 Nov 17.
2
Management of Systemic Medical Emergencies Associated with Psychotropic Medications.与精神药物相关的全身性医疗紧急情况的管理。
Indian J Psychiatry. 2022 Mar;64(Suppl 2):S252-S280. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_1014_21. Epub 2022 Mar 23.
3
Roles of inflammation in intrinsic pathophysiology and antipsychotic drug-induced metabolic disturbances of schizophrenia.炎症在精神分裂症固有病理生理学和抗精神病药物引起的代谢紊乱中的作用。
Behav Brain Res. 2021 Mar 26;402:113101. doi: 10.1016/j.bbr.2020.113101. Epub 2021 Jan 14.
4
Lurasidone-induced anemia: Is there a need for hematological monitoring?鲁拉西酮致贫血：是否需要进行血液学监测？
Indian J Pharmacol. 2019 Jul-Aug;51(4):276-278. doi: 10.4103/ijp.IJP_434_18.
本文引用的文献
1
Late Onset Agranulocytosis with Clozapine Associated with HLA DR4 Responding to Treatment with Granulocyte Colony-stimulating Factor: A Case Report and Review of Literature.迟发性氯氮平相关性粒细胞缺乏症与 HLA-DR4 相关，用粒细胞集落刺激因子治疗有效：病例报告及文献复习。
Clin Psychopharmacol Neurosci. 2016 May 31;14(2):212-7. doi: 10.9758/cpn.2016.14.2.212.
2
A case with neutropenia related with the use of various atypical antipsychotics.一例与使用各种非典型抗精神病药物相关的中性粒细胞减少症。
Psychiatry Investig. 2013 Dec;10(4):428-31. doi: 10.4306/pi.2013.10.4.428. Epub 2013 Dec 16.
3
Does switching to another antipsychotic in patients with clozapine-associated granulocytopenia solve the problem? Case series of 18 patients.换用另一种抗精神病药治疗氯氮平相关性粒细胞减少症患者能否解决问题？18 例病例系列。
J Clin Psychopharmacol. 2011 Apr;31(2):169-73. doi: 10.1097/JCP.0b013e31820e3d9d.
4
Neutropenia associated with quetiapine, olanzapine, and aripiprazole.与喹硫平、奥氮平和阿立哌唑相关的中性粒细胞减少症。
Aust N Z J Psychiatry. 2011 Jan;45(1):89. doi: 10.3109/00048674.2010.524624. Epub 2010 Nov 9.
5
Neutropenia induced by second generation antipsychotics: a prospective investigation.第二代抗精神病药引起的中性粒细胞减少症：一项前瞻性研究。
Pharmacopsychiatry. 2010 Mar;43(2):41-4. doi: 10.1055/s-0030-1249071. Epub 2010 Feb 19.
6
Haematological toxicity of drugs used in psychiatry.精神病学用药的血液学毒性。
Hum Psychopharmacol. 2008 Jan;23 Suppl 1:27-41. doi: 10.1002/hup.917.
7
Neuroleptic-induced neutropenia in the elderly.
J Am Geriatr Soc. 1987 Mar;35(3):248-50. doi: 10.1111/j.1532-5415.1987.tb02317.x.
8
Agranulocytosis and significant leucopenia with neuroleptic drugs: results from the AMUP program.
Psychopharmacology (Berl). 1989;99 Suppl:S109-12. doi: 10.1007/BF00442573.
9
A review of clozapine: an antipsychotic for treatment-resistant schizophrenia.氯氮平综述：一种用于治疗难治性精神分裂症的抗精神病药物。
Compr Psychiatry. 1990 Jul-Aug;31(4):315-26. doi: 10.1016/0010-440x(90)90038-t.
10
Leukopenia following treatment with thiothixene and haloperidol.
JAMA. 1979 Dec 28;242(26):2872-3.
Zotero 插件