Sood Shabnam
Maricopa Integrated Health System/District Medical Group, University of Arizona School of Medicine, Phoenix, AZ, USA.
Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):413-415. doi: 10.9758/cpn.2017.15.4.413.
Antipsychotic-induced agranulocytosis is a significant side effect that is known to occur with most of the antipsychotic medications. It usually resolves once the medications are stopped and patients are able to be switched over to another antipsychotic medication. Lurasidone has not been reported to cause leukopenia and neutropenia. This case report is of a patient with a past history of risperidone induced-aganulocytosis developing dose related leukopenia and neutropenia with lurasidone.
抗精神病药物所致粒细胞缺乏症是一种严重的副作用,已知大多数抗精神病药物都可引发。一旦停用这些药物,且患者能够换用其他抗精神病药物,该副作用通常会消失。目前尚未有关于鲁拉西酮导致白细胞减少和中性粒细胞减少的报道。本病例报告的患者既往有服用利培酮引发粒细胞缺乏症的病史,此次服用鲁拉西酮后出现了与剂量相关的白细胞减少和中性粒细胞减少。