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一种从桃金娘茎中提取的新的柯里洛鞣花酸衍生物。

A new coruleoellagic acid derivative from stems of Rhodamnia dumetorum.

作者信息

Lakornwong Waranya, Kanokmedhakul Kwanjai, Kanokmedhakul Somdej

机构信息

a Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science , Khon Kaen University , Khon Kaen , Thailand.

出版信息

Nat Prod Res. 2018 Jul;32(14):1653-1659. doi: 10.1080/14786419.2017.1395430. Epub 2017 Oct 26.

Abstract

A new coruleoellagic acid derivative, 3,3',4,4',5'-pentamethylcoruleoellagic acid (1) together with nine known compounds, hexamethylcoruleoellagic acid (2), 3,4,3'-tri-O-methylellagic acid (3), heptaphylline (4), 7-methoxymukonal (5), dentatin (6), sinapaldehyde (7), gallic acid (8), 2,6-dimethoxy-4H-pyran-4-one (9) and β-sitosterol (10) were isolated from the stems of Rhodamnia dumetorum. Their structures were identified by physical and spectroscopic data (IR, 1D and 2D NMR, and MS). Compounds 1, 2 and 7-10 were tested for antibacterial activity against six pathogenic bacterial strains (Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica serovar Typhimurium, Staphylococcus aureus, and Methicillin resistant S. aureus (MRSA)).

摘要

从桃金娘科玫瑰木的茎中分离得到一种新的柯里栎鞣花酸衍生物3,3',4,4',5'-五甲基柯里栎鞣花酸(1)以及9种已知化合物,即六甲基柯里栎鞣花酸(2)、3,4,3'-三-O-甲基鞣花酸(3)、七叶树碱(4)、7-甲氧基慕康醛(5)、齿孔酸(6)、芥子醛(7)、没食子酸(8)、2,6-二甲氧基-4H-吡喃-4-酮(9)和β-谷甾醇(10)。通过物理和光谱数据(红外光谱、一维和二维核磁共振光谱以及质谱)确定了它们的结构。对化合物1、2和7-10针对6种致病菌株(蜡样芽孢杆菌、大肠杆菌、铜绿假单胞菌、鼠伤寒沙门氏菌、金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌(MRSA))进行了抗菌活性测试。

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