冬眠五趾跳鼠（东方五趾跳鼠）白色脂肪组织脂解的激素调控

Hormonal control of lipolysis from the white adipose tissue of hibernating jerboa (Jaculus orientalis).

Moreau-Hamsany C, Castex C, Hoo-Paris R, Kacemi N, Sutter B

Endocrinology Department, University of Bordeaux I, Talence, France.

Comp Biochem Physiol A Comp Physiol. 1988;91(4):665-9. doi: 10.1016/0300-9629(88)90945-0.

Abstract

Plasma glucose, glycerol, free fatty acids and total lipid content of the white adipose tissue were measured in euthermic and hibernating jerboa. 2. During hibernation, plasma glucose and glycerol were low compared to the euthermic animals, whereas there was no obvious difference in plasma free fatty acids. The white adipose tissue lipid content was strongly reduced in the hibernating state. 3. The effect of lipolytic hormones (norepinephrine and glucagon) and antilipolytic hormone (insulin) on in vitro glycerol release by adipose tissue isolated from hibernating or euthermic jerboa has been studied. 4. The white adipose tissue from hibernating jerboa presented a higher sensitivity to norepinephrine and glucagon than that of euthermic jerboa; insulin did not modify either basal glycerol release or lipolysis induced by the two lipolytic hormones at low temperatures (7 degrees C) and during the rewarming (from 7 degrees C to 37 degrees C) of the tissue slices. 5. These results suggested that white adipose tissue constitutes an important source of substrates derived from lipolysis during hibernation.

摘要

测定了正常体温和冬眠状态的跳鼠的血浆葡萄糖、甘油、游离脂肪酸及白色脂肪组织的总脂质含量。2. 在冬眠期间，与正常体温的动物相比，血浆葡萄糖和甘油含量较低，而血浆游离脂肪酸没有明显差异。冬眠状态下白色脂肪组织的脂质含量大幅降低。3. 研究了脂解激素（去甲肾上腺素和胰高血糖素）和抗脂解激素（胰岛素）对从冬眠或正常体温的跳鼠分离的脂肪组织体外甘油释放的影响。4. 冬眠跳鼠的白色脂肪组织对去甲肾上腺素和胰高血糖素的敏感性高于正常体温的跳鼠；在低温（7摄氏度）及组织切片复温（从7摄氏度至37摄氏度）过程中，胰岛素对基础甘油释放或两种脂解激素诱导的脂解均无影响。5. 这些结果表明，白色脂肪组织是冬眠期间脂解产生的重要底物来源。