Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, United States.
Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, United States.
Brain Behav Immun. 2018 Mar;69:57-59. doi: 10.1016/j.bbi.2017.10.020. Epub 2017 Oct 23.
Altered immune function and inflammation are seen in schizophrenia, however, peripheral inflammatory markers are not consistently elevated in all people, suggesting inflammation may be present only in a subgroup. We measured TNF-α and IL-Iβ in 100 people with schizophrenia or schizoaffective disorder and correlated these with antibodies to gliadin, a protein found in wheat, barley and rye that has been found to be elevated in some people with schizophrenia. We hypothesized that higher peripheral antigliadin antibodies (AGA IgG) would be associated with higher peripheral inflammation as measured by TNF-α and IL-1β. Mean log transformed values of TNF-α, (p=.029) and IL-1β (p=.016) were over twofold higher in people with schizophrenia who had high levels of AGA IgG (≥7 U) compared to those who did not have positivity to AGA IgG. We found a significant positive correlation between AGA IgG and the log transformed TNF-α (r=0.42, p<.0001) as well as IL-Iβ (r=0.51, p<.0001). The relationship was independent of cigarette smoking, body mass index and antipsychotic medications. People with schizophrenia having higher levels of AGA IgG show higher levels of peripheral inflammation and may define a subgroup with distinct pathophysiology and potentially novel treatment targets.
精神分裂症患者的免疫功能和炎症发生改变，然而，并非所有患者的外周炎症标志物都持续升高，这表明炎症可能仅存在于亚组中。我们测量了 100 名精神分裂症或分裂情感障碍患者的 TNF-α 和 IL-1β，并将这些与抗麦胶蛋白抗体相关联，麦胶蛋白是一种存在于小麦、大麦和黑麦中的蛋白质，一些精神分裂症患者的抗麦胶蛋白抗体升高。我们假设，外周抗麦胶蛋白抗体（AGA IgG）水平较高与 TNF-α 和 IL-1β 等外周炎症标志物水平升高有关。与 AGA IgG 阴性的患者相比，AGA IgG 水平较高（≥7 U）的精神分裂症患者的 TNF-α（p=.029）和 IL-1β（p=.016）的平均对数转换值高出两倍以上。我们发现 AGA IgG 与 TNF-α（r=0.42，p<.0001）和 IL-Iβ（r=0.51，p<.0001）的对数转换值呈显著正相关。这种关系独立于吸烟、体重指数和抗精神病药物。AGA IgG 水平较高的精神分裂症患者表现出更高水平的外周炎症，可能定义了一个具有独特病理生理学和潜在新治疗靶点的亚组。
