miRNAs 和长非编码 RNA 在糖尿病视网膜病变进展中的作用。
Roles of miRNAs and long noncoding RNAs in the progression of diabetic retinopathy.
机构信息
Eye Center, The Second Hospital of Jilin University, #218 Ziqiang Street, Changchun, Jilin 130021, China.
Eye Center, The Second Hospital of Jilin University, #218 Ziqiang Street, Changchun, Jilin 130021, China
出版信息
Biosci Rep. 2017 Nov 29;37(6). doi: 10.1042/BSR20171157. Print 2017 Dec 22.
Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults across the world. The pathogenesis of DR is multifactorial and the molecular mechanisms are still not fully understood. Accumulating evidence has demonstrated that noncoding RNAs (ncRNAs) may be aberrantly expressed and may play vital roles in the development of DR. Amongst ncRNAs, miRNAs and long ncRNAs (lncRNAs) are known for their regulatory functions. Here, we summarize the functions and mechanisms of known aberrantly expressed miRNAs and lncRNAs in DR. Additionally, a novel lncRNA-mRNA-miRNA network is included in this review. We highlight original studies that provide detailed data about the mechanisms of miRNAs and lncRNAs, their applications as diagnostic or prognostic biomarkers, and their potential therapeutic targets. In conclusion, this review will help us gain a better understanding of the molecular mechanisms by which miRNAs and lncRNAs perform their functions in DR, and provide general strategies and directions for future research.
糖尿病视网膜病变（DR）是全球导致工作年龄成年人失明的主要原因。DR 的发病机制是多因素的，其分子机制尚不完全清楚。越来越多的证据表明，非编码 RNA（ncRNA）可能异常表达，并可能在 DR 的发展中发挥重要作用。在 ncRNA 中，miRNAs 和长链非编码 RNA（lncRNAs）以其调节功能而闻名。在这里，我们总结了已知在 DR 中异常表达的 miRNAs 和 lncRNAs 的功能和机制。此外，本综述还包括一个新的 lncRNA-mRNA-miRNA 网络。我们重点介绍了提供有关 miRNAs 和 lncRNAs 机制、作为诊断或预后生物标志物的应用以及潜在治疗靶点的详细数据的原始研究。总之，本综述将帮助我们更好地了解 miRNAs 和 lncRNAs 在 DR 中发挥作用的分子机制，并为未来的研究提供通用的策略和方向。
Zotero 插件