Quistad G B, Saunders A L, Skinner W S, Collier K D, Sakai D H, Reuter C C
Sandoz Crop Protection Corporation, Zoecon Research Institute, Palo Alto, CA 94303-0859.
Drug Metab Dispos. 1988 Nov-Dec;16(6):818-22.
Metabolism of [benzyl-14C]fluvalinate by chickens produces 3-phenoxybenzoic acid, which is further degraded by two new pathways. The first pathway involves O-dephenylation, not reported previously for related pyrethroids in birds or mammals. O-Dephenylation is a major metabolic route (12% of the applied 14C). In the second pathway, 2% of the applied dose is converted into four conjugates of benzoylornithine (two with 3-hydroxybenzoic and two with 3-phenoxybenzoic acids). The predominant conjugate with benzoylornithine is N2-(3-hydroxybenzoyl)-N5-benzoylornithine.
