Surprising Enhancement of Fibrosis by Tubule-Specific Deletion of the TGF- Receptor: A New Twist on an Old Paradigm.
作者信息
Basile David P, Mehrotra Purvi
机构信息
Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, Indiana
Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, Indiana.
出版信息
J Am Soc Nephrol. 2017 Dec;28(12):3427-3429. doi: 10.1681/ASN.2017080947. Epub 2017 Oct 26.
Abstract
摘要
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Blocking TGF- and -Catenin Epithelial Crosstalk Exacerbates CKD.阻断转化生长因子和β-连环蛋白上皮细胞串扰会加剧慢性肾脏病。
J Am Soc Nephrol. 2017 Dec;28(12):3490-3503. doi: 10.1681/ASN.2016121351. Epub 2017 Jul 12.
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Anti-TGF-1 Antibody Therapy in Patients with Diabetic Nephropathy.抗转化生长因子-1抗体疗法治疗糖尿病肾病患者
J Am Soc Nephrol. 2017 Mar;28(3):953-962. doi: 10.1681/ASN.2015111230. Epub 2016 Sep 19.
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Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.对豪猪介导的Wnt O-酰化的实验性抑制可减轻肾纤维化。
Kidney Int. 2016 May;89(5):1062-1074. doi: 10.1016/j.kint.2016.01.017. Epub 2016 Mar 25.
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TGF-β signaling in the kidney: profibrotic and protective effects.肾脏中的转化生长因子-β信号传导：促纤维化和保护作用。
Am J Physiol Renal Physiol. 2016 Apr 1;310(7):F596-F606. doi: 10.1152/ajprenal.00365.2015. Epub 2016 Jan 6.
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Development of anticancer agents targeting the Wnt/β-catenin signaling.靶向Wnt/β-连环蛋白信号通路的抗癌药物研发
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Kidney Int Suppl (2011). 2014 Nov;4(1):84-90. doi: 10.1038/kisup.2014.16.
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Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice.糖原合酶激酶-3抑制可减轻小鼠肾缺血再灌注后成纤维细胞活化及纤维化发展。
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