Department of Bioengineering and the Helen Wills Neuroscience Institute, University of California-Berkeley, Berkeley, CA 94708, USA. Email:
Science. 2017 Oct 27;358(6362):466-469. doi: 10.1126/science.aan8865.
The neuroscience field is steaming ahead, fueled by a revolution in cutting-edge technologies. Concurrently, another revolution has been underway-the diversity of species utilized for neuroscience research is sharply declining, as the field converges on a few selected model organisms. Here, from the perspective of a young scientist, I naively ask: Is the great diversity of questions in neuroscience best studied in only a handful of animal models? I review some of the limitations the field is facing following this convergence and how these can be rectified by increasing the diversity of appropriate model species. I propose that at this exciting time of revolution in genetics and device technologies, neuroscience might be ready to diversify again, if provided the appropriate support.
神经科学领域正在蓬勃发展,得益于尖端技术的革命。与此同时,另一场革命正在进行——用于神经科学研究的物种多样性急剧下降,因为该领域集中在少数几种选定的模式生物上。在这里,作为一名年轻的科学家,我天真地问:神经科学中如此多样化的问题是否只能通过少数几种动物模型来研究?我回顾了该领域在这种趋同后面临的一些限制,以及通过增加适当模型物种的多样性如何可以纠正这些限制。我提出,如果提供适当的支持,那么在遗传学和设备技术的革命性变革的这个激动人心的时刻,神经科学可能再次准备好多样化。