Yamauchi Mika, Sugimoto Toshitsugu
Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
Clin Calcium. 2017;27(11):1561-1569.
Numerous epidemiological studies and meta-analyses have indicated that there is a link between Vitamin D insufficiency/deficiency and metabolic disorders such as type 1 and type 2 diabetes mellitus as well as metabolic syndrome. However, vitamin D supplementation has not demonstrated improvement effects in obesity, disorders of glucose and lipid metabolism in any of these illnesses;therefore, the details of the causal relationship remain unclear. Improvement in glucose metabolism was observed in a study in which only vitamin D deficient patients with 25-hydroxyvitamin D[25(OH)D]levels of less than 20 ng/mL were given native vitamin D supplementation. Further studies are needed to determine the 25(OH)D level at which intervention is needed along with the required amount and duration of such supplementation.
众多流行病学研究和荟萃分析表明，维生素D不足/缺乏与1型和2型糖尿病以及代谢综合征等代谢紊乱之间存在联系。然而，补充维生素D在这些疾病中的肥胖、糖脂代谢紊乱方面均未显示出改善效果；因此，因果关系的具体细节仍不清楚。在一项研究中，仅对25-羟基维生素D[25(OH)D]水平低于20 ng/mL的维生素D缺乏患者给予天然维生素D补充剂，观察到糖代谢有所改善。需要进一步研究以确定需要进行干预的25(OH)D水平以及这种补充剂所需的剂量和持续时间。
