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[维生素D研究近期进展更新。 eldecalcitol与预防跌倒]

[Update on recent progress in vitamin D research. Eldecalcitol and Fall Prevention].

作者信息

Suzuki Takao

机构信息

Institute of Gerontology, J.F. Oberlin University, Tokyo/National Center for Geriatrics and Gerontology, Aichi, Japan.(former).

出版信息

Clin Calcium. 2017;27(11):1595-1600.

Abstract

In the elderly, vitamin D deficiency results not only in impaired bone mineralization, but also myopathy. Low vitamin D has also been shown to be associated with decline of muscle strength, sarcopenia, functional limitation, and disability. Several recent studies have shown that low serum vitamin D concentration is associated with lower physical function and falls in older adults. In this article, the author reviews a relationship between falls and serum vitamin D concentration of the elderly living in the community, and also introduces the major results from a recent randomized controlled trial on prevention of decline of fall-related balance performance by the treatment with newly developed active vitamin D(Eldecalcitol )among the women with age 65 years old and over and diagnosed as osteoporosis.

摘要

在老年人中,维生素D缺乏不仅会导致骨矿化受损,还会引起肌病。低维生素D水平还与肌肉力量下降、肌肉减少症、功能受限和残疾有关。最近的几项研究表明,血清维生素D浓度低与老年人身体功能下降和跌倒有关。在本文中,作者回顾了社区老年人跌倒与血清维生素D浓度之间的关系,并介绍了一项最近的随机对照试验的主要结果,该试验针对65岁及以上被诊断为骨质疏松症的女性,采用新开发的活性维生素D( eldecalcitol)治疗,以预防与跌倒相关的平衡能力下降。

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