Wellcome Trust Sanger Institute, Cambridge, UK.
Nat Genet. 2017 Oct 27;49(11):1564-1565. doi: 10.1038/ng.3982.
High-resolution maps of enhancer-promoter interactions in rare primary human T cell subsets and coronary artery smooth muscle cells link variants associated with autoimmune and cardiovascular diseases to target genes. This represents an important step forward for mapping genes involved in complex diseases.
高分辨率图谱描绘了罕见原发性人类 T 细胞亚群和冠状动脉平滑肌细胞中的增强子-启动子相互作用，将与自身免疫和心血管疾病相关的变体与靶基因联系起来。这代表了在绘制复杂疾病相关基因图谱方面向前迈出的重要一步。
