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环境中的精神药物:利培酮残留会影响鱼类幼体的行为。

Psychotropic in the environment: risperidone residues affect the behavior of fish larvae.

机构信息

Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.

Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.

出版信息

Sci Rep. 2017 Oct 26;7(1):14121. doi: 10.1038/s41598-017-14575-7.

Abstract

The ability to avoid and escape from predators are clearly relevant behaviors from the ecological perspective and directly interfere with the survival of organisms. Detected in the aquatic environment, risperidone can alter the behavior of exposed species. Considering the risk of exposure in the early stages of life, we exposed zebrafish embryos to risperidone during the first 5 days of life. Risperidone caused hyperactivity in exposed larvae, which in an environmental context, the animals may be more vulnerable to predation due to greater visibility or less perception of risk areas.

摘要

从生态学的角度来看,避免和逃避捕食者的能力显然是相关的行为,直接影响到生物体的生存。在水生环境中检测到,利培酮可以改变暴露物种的行为。考虑到生命早期暴露的风险,我们在生命的头 5 天让斑马鱼胚胎暴露于利培酮中。利培酮使暴露的幼虫变得过度活跃,在环境背景下,由于动物的可见度更高或对危险区域的感知能力降低,它们可能更容易受到捕食。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d06/5658348/34918977ccc5/41598_2017_14575_Fig1_HTML.jpg

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