Chaurasia Rahul, Rout Diptiranjan, Dogra Kanchan, Coshic Poonam, Chatterjee Kabita
Department of Transfusion Medicine, AIIMS, New Delhi, India.
Indian J Hematol Blood Transfus. 2017 Dec;33(4):628-629. doi: 10.1007/s12288-017-0788-x. Epub 2017 Feb 4.
Though not very frequent, blood group discrepancies are of common occurrence which must be promptly resolved for safe transfusion practices. Blood group discrepancy is defined as the non-corroboration between cell grouping and serum grouping. Variable erythrocyte antigenic expressions (qualitative and/or quantitative difference) owing to allelic heterogeneity, give rise to subgroups. Problems during blood grouping due to weakened expression of antigens are a rare cause for ABO discrepancies. Of note, subgroups of 'B' with decreased expression of the B antigen are of very rare occurrence in the general population. Serologically, the variants of 'B' can be classified into B, B, B and B. Serological confirmation of such subgroups requires special immuno-haematological procedures. The current study reports 3 cases of subgroups of B (2 cases of B and 1 case of B) detected at our centre. It is important to detect and resolve discrepant ABO grouping results so as to prevent ABO mis-match transfusions. Such individuals should also be pre-emptively informed of their respective blood donor and transfusion recipient status, as well.
尽管血型不符并不十分常见，但却是经常发生的情况，为了安全输血，必须迅速解决。血型不符被定义为细胞分组和血清分组之间的不一致。由于等位基因异质性导致的可变红细胞抗原表达（定性和/或定量差异）会产生亚群。抗原表达减弱导致血型鉴定过程中出现问题是ABO血型不符的罕见原因。值得注意的是，B抗原表达降低的B亚型在普通人群中非常罕见。血清学上，B的变体可分为B、B、B和B。此类亚群的血清学确认需要特殊的免疫血液学程序。本研究报告了在我们中心检测到的3例B亚型病例（2例B和1例B）。检测并解决不一致的ABO血型鉴定结果很重要，以防止ABO血型不匹配输血。还应提前告知此类个体他们各自的献血者和输血接受者状态。
