健康献血者中A血型和AB血型人群中A2及A2B亚群的发生率。
Prevalence of A2 and A2B Subgroups among Blood Groups A and AB in healthy donors.
作者信息
Khanum Ayesha, Farhan Saima, Saqlain Nazish, Arshad Sundas
机构信息
Ayesha Khanum, FCPS. Consultant Hematologist, University of Child Health Sciences, The Children's Hospital, Lahore, Pakistan.
Saima Farhan FCPS. Associate Professor of Paeds. Haematology, University of Child Health Sciences, The Children's Hospital, Lahore, Pakistan.
出版信息
Pak J Med Sci. 2024 Jan-Feb;40(1Part-I):156-158. doi: 10.12669/pjms.40.1.7916.
OBJECTIVE
To determine the frequency of A2 and A2B subgroups among blood groups A and AB in healthy donors.
METHODS
It was a Cross-Sectional study, conducted at the Department of Hematology & Transfusion Medicine, UCHS, The Children's Hospital Lahore and Sundas foundation Lahore from June 2022 to December 2022 including 13,120 healthy blood donors of both genders, after taking informed consent. Venous blood samples of donors were collected in EDTA vials (3ml) and serum gel vial for routine blood grouping which was done by standard tube method. Further testing of donors positive for an antigen (blood Group-A and AB) was performed using anti-A1 lectin by standard tube method as per manufacturer's instruction. The data was analyzed using SPSS version 23.
RESULTS
Among 13120 blood donors, 12857 (97.9%) were male and 263 (2.0%) were female with mean age of 36.7 years ± 15.04 years. Majority of them (91.7%) were of Punjabi ethnicity. Donors having blood group phenotype A and AB were 3890 (29.6%). Among blood Group-A donors, A1 was found in 97.8% and A2 in 2.2% donors. While among Blood Group-AB, 96.7% donors belonged to A1B blood group and 3.2% belonged to A2B blood group.
CONCLUSIONS
Blood group A2 and A2B do exist in blood donors of Punjabi ethnicity. The knowledge of presence of these blood groups' phenotypes in our population can provide a better base for transfusion staff to do troubleshooting in compatibility testing and to avoid any rare but hazardous transfusion outcome.
目的
确定健康献血者中A血型和AB血型人群中A2及A2B亚群的出现频率。
方法
这是一项横断面研究，于2022年6月至2022年12月在拉合尔儿童医院UCHS血液学与输血医学系以及拉合尔桑达斯基金会开展，纳入13120名获得知情同意的健康男女献血者。将献血者的静脉血样本采集到EDTA试管（3毫升）和血清凝胶试管中，采用标准试管法进行常规血型鉴定。按照制造商的说明，使用抗A1凝集素通过标准试管法对A抗原阳性的献血者（A血型和AB血型）进行进一步检测。使用SPSS 23版软件对数据进行分析。
结果
在13120名献血者中，男性12857名（97.9%），女性263名（2.0%），平均年龄为36.7岁±15.04岁。其中大多数（91.7%）为旁遮普族。血型表型为A和AB的献血者有3890名（29.6%）。在A型献血者中，97.8%的献血者为A1型，2.2%为A2型。而在AB型献血者中，96.7%的献血者属于A1B血型，3.2%属于A2B血型。
结论
旁遮普族献血者中确实存在A2和A2B血型。了解我们人群中这些血型表型的存在情况可为输血工作人员在相容性检测中进行故障排除以及避免任何罕见但危险的输血结果提供更好的依据。
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