Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.
Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
Surg Endosc. 2018 Mar;32(3):1434-1440. doi: 10.1007/s00464-017-5827-z. Epub 2017 Oct 26.
The number of elderly patients with colon cancer is increasing in Japan. Postoperative delirium (POD) is a major complication for elderly patients who undergo surgery, and postoperative pain is a common inducer of POD. We reported previously that single-incision laparoscopic surgery (SLS) significantly reduces postoperative pain compared to conventional laparoscopic surgery (CLS). Data are lacking about the effect of SLS on POD. This retrospective study evaluated the clinical benefits of SLS for POD in elderly patients with colon cancer.
This retrospective case-control study included colon cancer patients (n = 134) over 75 years old who underwent elective surgery from 2009 to 2015 at Osaka University Hospital. Of these patients, 110 were evaluated using the comprehensive geriatric assessment (CGA) before surgery and were classified into lower or higher risk groups based on their scores.
The rate of POD was significantly lower in the SLS group than the CLS group (13.8% vs. 30.0%; p = 0.0161). In the CGA-based higher risk group, the rate of POD was significantly higher in the CLS group than the SLS group (p = 0.0153).
SLS for elderly colon cancer patients may lower the incidence of POD compared with CLS.
日本老年结肠癌患者数量不断增加。术后谵妄(POD)是老年手术患者的主要并发症,而术后疼痛是 POD 的常见诱因。我们之前曾报道过,与传统腹腔镜手术(CLS)相比,单切口腹腔镜手术(SLS)可显著减轻术后疼痛。关于 SLS 对 POD 的影响的数据尚缺乏。本回顾性研究评估了 SLS 对老年结肠癌患者 POD 的临床益处。
本回顾性病例对照研究纳入了 2009 年至 2015 年在大阪大学医院接受择期手术的 75 岁以上结肠癌患者(n=134)。这些患者在手术前均接受了全面老年评估(CGA),并根据评分分为低危或高危组。
SLS 组的 POD 发生率明显低于 CLS 组(13.8% vs. 30.0%;p=0.0161)。在基于 CGA 的高危组中,CLS 组的 POD 发生率明显高于 SLS 组(p=0.0153)。
与 CLS 相比,SLS 治疗老年结肠癌患者可能会降低 POD 的发生率。