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Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.

作者信息

Segatto O, King C R, Pierce J H, Di Fiore P P, Aaronson S A

机构信息

Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892.

出版信息

Mol Cell Biol. 1988 Dec;8(12):5570-4. doi: 10.1128/mcb.8.12.5570-5574.1988.

DOI:10.1128/mcb.8.12.5570-5574.1988
PMID:2907606
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC365664/
Abstract

Compared with normal erbB-2 gp185, mutant erbB-2 proteins generated by mutations either in the transmembrane domain or by NH2-terminal deletion are able to transform NIH 3T3 cells at a 10- to 100-fold greater efficiency. Mutant proteins of both classes show increased tyrosine kinase activity, suggesting that an abnormal level of receptor-associated tyrosine kinase activity is a major determinant of erbB-2 oncogenic potential.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb01/365664/a8b7506e3652/molcellb00072-0525-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb01/365664/3f4040d02c06/molcellb00072-0523-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb01/365664/c48040970c2c/molcellb00072-0523-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb01/365664/326027ee9f9b/molcellb00072-0524-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb01/365664/a8b7506e3652/molcellb00072-0525-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb01/365664/3f4040d02c06/molcellb00072-0523-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb01/365664/c48040970c2c/molcellb00072-0523-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb01/365664/326027ee9f9b/molcellb00072-0524-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb01/365664/a8b7506e3652/molcellb00072-0525-a.jpg

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1
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Mol Cell Biol. 1988 Dec;8(12):5570-4. doi: 10.1128/mcb.8.12.5570-5574.1988.
2
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本文引用的文献

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Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts.将癌和神经母细胞瘤的转化基因导入小鼠成纤维细胞。
Nature. 1981 Mar 19;290(5803):261-4. doi: 10.1038/290261a0.
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The neu oncogene encodes an epidermal growth factor receptor-related protein.神经癌基因编码一种与表皮生长因子受体相关的蛋白质。
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Rapid and efficient site-specific mutagenesis without phenotypic selection.无需表型筛选的快速高效位点特异性诱变。
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Spatial-Division Multiplexing Approach for Simultaneous Detection of Fiber-Optic Ball Resonator Sensors: Applications for Refractometers and Biosensors.基于空分复用技术的光纤球谐振器传感器同时检测方法：应用于折光仪和生物传感器。
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It Takes More than Two to Tango: Complex, Hierarchal, and Membrane-Modulated Interactions in the Regulation of Receptor Tyrosine Kinases.一个巴掌拍不响：受体酪氨酸激酶调控中的复杂、层级化及膜调节相互作用
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Perspectives, Therapies, and Challenges for Metastatic HER2-Positive Breast Cancer.转移性HER2阳性乳腺癌的观点、治疗方法及挑战
Breast Cancer (Dove Med Press). 2021 Sep 24;13:539-557. doi: 10.2147/BCTT.S288344. eCollection 2021.
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Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells.选择性 ERBB2 和 BCL2 抑制协同作用促进 MDS 和 AML 细胞中线粒体介导的细胞凋亡。
Mol Cancer Res. 2021 May;19(5):886-899. doi: 10.1158/1541-7786.MCR-20-0973. Epub 2021 Jan 29.
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Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion.通过 ErbB2 诱导的、SUMO 定向的髓系锌指蛋白 1 丝氨酸 27 磷酸化来释放转录抑制，激活溶酶体重分布和侵袭。
Oncogene. 2019 Apr;38(17):3170-3184. doi: 10.1038/s41388-018-0653-x. Epub 2019 Jan 8.
10
Dynamics of Axl Receptor Shedding in Hepatocellular Carcinoma and Its Implication for Theranostics.肝细胞癌中 Axl 受体脱落的动力学及其治疗学意义。
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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.人类乳腺癌：HER-2/neu癌基因扩增与复发及生存的相关性。
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Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor.表皮生长因子可诱导纯化的表皮生长因子受体快速、可逆地聚集。
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Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation.表皮生长因子受体的自身磷酸化：分子间变构激活模型的证据
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Frequent generation of oncogenes by in vitro recombination of TRK protooncogene sequences.
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