红细胞生成及相关疾病的小鼠模型
Mouse Models of Erythropoiesis and Associated Diseases.
作者信息
Parker Matthew P, Peterson Kenneth R
机构信息
Department of Biochemistry and Molecular Biology, MS3030, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.
Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.
出版信息
Methods Mol Biol. 2018;1698:37-65. doi: 10.1007/978-1-4939-7428-3_3.
Abstract
Animal models of erythropoiesis have been, and will continue to be, important tools for understanding molecular mechanisms underlying the development of this cell lineage and the pathophysiology associated with various human erythropoietic diseases. In this regard, the mouse is probably the most valuable animal model available to investigators. The physiology and short gestational period of mice make them ideal for studying developmental processes and modeling human diseases. These attributes, coupled with cutting-edge genetic tools such as transgenesis, gene knockouts, conditional gene knockouts, and genome editing, provide a significant resource to the research community to test a plethora of hypotheses. This review summarizes the mouse models available for studying a wide variety of erythroid-related questions, as well as the properties inherent in each one.
摘要
红细胞生成的动物模型一直是且将继续是理解该细胞谱系发育的分子机制以及与各种人类红细胞生成疾病相关的病理生理学的重要工具。在这方面，小鼠可能是研究人员可用的最有价值的动物模型。小鼠的生理学特性和较短的妊娠期使其成为研究发育过程和模拟人类疾病的理想选择。这些特性，再加上诸如转基因、基因敲除、条件性基因敲除和基因组编辑等前沿遗传工具，为研究界提供了大量资源，以检验大量假设。本综述总结了可用于研究各种与红细胞相关问题的小鼠模型，以及每个模型所固有的特性。
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