中性粒细胞与淋巴细胞比值在头颈癌中的预后作用：一项荟萃分析。
Prognostic role of neutrophil-to-lymphocyte ratio in head and neck cancer: A meta-analysis.
作者信息
Takenaka Yukinori, Oya Ryohei, Kitamiura Takahiro, Ashida Naoki, Shimizu Kotaro, Takemura Kazuya, Yamamoto Yoshifumi, Uno Atsuhiko
机构信息
Department of Otorhinolaryngology - Head and Neck Surgery, Osaka General Medical Center, Osaka, Japan.
出版信息
Head Neck. 2018 Mar;40(3):647-655. doi: 10.1002/hed.24986. Epub 2017 Oct 27.
BACKGROUND
Neutrophils play substantial roles in cancer progression. Previous reports demonstrated the prognostic impact of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in various types of solid cancers. The purpose of this study was to quantify the prognostic impact of NLR on head and neck squamous cell carcinoma (HNSCC).
METHODS
We systematically searched electronic databases, identified articles regarding NLR and HNSCC mortality, and extracted hazard ratios (HRs) and 95% confidence intervals (CIs). Pooled HRs for overall survival (OS) and disease-specific survival (DSS) were estimated using random effect models.
RESULTS
Nineteen studies enrolling 3770 patients were included in the analyses. Overall, NLR greater than the cutoff value was associated with poorer OS and DSS (HR 1.69; 95% CI 1.47-1.93; P < .001 and HR 1.88; 95% CI 1.20-2.95; P = .006, respectively).
CONCLUSION
Elevated NLR predicts worse outcomes in patients with HNSCC.
背景
中性粒细胞在癌症进展中发挥着重要作用。先前的报告显示了预处理中性粒细胞与淋巴细胞比值（NLR）对各种实体癌的预后影响。本研究的目的是量化NLR对头颈部鳞状细胞癌（HNSCC）的预后影响。
方法
我们系统地检索了电子数据库，识别了有关NLR和HNSCC死亡率的文章，并提取了风险比（HRs）和95%置信区间（CIs）。使用随机效应模型估计总生存期（OS）和疾病特异性生存期（DSS）的合并HRs。
结果
纳入分析的有19项研究，共3770例患者。总体而言，NLR大于临界值与较差的OS和DSS相关（HR 1.69；95%CI 1.47 - 1.93；P <.001和HR 1.88；95%CI 1.20 - 2.95；P =.006）。
结论
NLR升高预示HNSCC患者预后较差。
Zotero 插件