高预处理中性粒细胞与淋巴细胞比值可预测头颈部鳞状细胞癌患者的不良生存预后：系统评价和荟萃分析。
High pretreatment neutrophil-to-lymphocyte ratio as a predictor of poor survival prognosis in head and neck squamous cell carcinoma: Systematic review and meta-analysis.
机构信息
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
出版信息
Head Neck. 2019 May;41(5):1525-1535. doi: 10.1002/hed.25583. Epub 2018 Dec 30.
BACKGROUND
The prognostic roles of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been reported in head and neck squamous cell carcinoma (HNSCC), but their results remain controversial.
METHODS
A total of 25 literatures with 28 cohorts involving 6847 HNSCC patients were included. The hazard ratio (HR) was pooled with 95% confidence interval (CI) using fixed-effects or random-effects models.
RESULTS
High pretreatment NLR predicted poor overall survival (OS: HR = 1.68; 95% CI = 1.39-2.03; P < .001), disease-free survival (DFS: HR = 1.76; 95% CI = 1.42-2.17; P < .001), progression-free survival (PFS: HR = 1.53; 95% CI = 1.09-2.14; P = .014), and cancer-specific survival (CSS: HR = 1.45; 95% CI = 1.23-1.71; P < .001) in HNSCC. However, the association between PLR and OS or DFS was not statistically significant.
CONCLUSION
The NLR can serve as a potential prognostic biomarker for patients with HNSCC.
背景
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）在头颈部鳞状细胞癌（HNSCC）中的预后作用已有报道，但结果仍存在争议。
方法
共纳入 25 篇文献，涉及 28 个队列共 6847 例 HNSCC 患者。采用固定效应或随机效应模型，用 95%置信区间（CI）合并风险比（HR）。
结果
高术前 NLR 预测总生存期（OS：HR=1.68；95%CI=1.39-2.03；P<0.001）、无病生存期（DFS：HR=1.76；95%CI=1.42-2.17；P<0.001）、无进展生存期（PFS：HR=1.53；95%CI=1.09-2.14；P=0.014）和癌症特异性生存期（CSS：HR=1.45；95%CI=1.23-1.71；P<0.001）不良。然而，PLR 与 OS 或 DFS 之间的关联没有统计学意义。
结论
NLR 可作为 HNSCC 患者的潜在预后生物标志物。
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